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Lafaille, Maria A. Curotto de Lafaille 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (157 p.) 225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v388 300 $aDescription based upon print version of record. 311 $a3-319-13724-7 320 $aIncludes bibliographical references and index. 327 $aBiology of IgE Production: IgE Cell Differentiation and the Memory of IgE Responses -- Molecular Mechanisms of IgE Class Switch Recombination -- Anti-IgE Therapy: Clinical Utility and Mechanistic Insights -- New Insights on the Signaling and Function of the High Affinity Receptor for IgE -- Helminth-Induced IgE and Protection Against Allergic Disorders -- IgE Immunotherapy Against Cancer. 330 $aThis volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites. It highlights the unique mechanisms involved in the regulation of IgE production at both the molecular and cellular level. Furthermore, it discusses in detail novel findings on how the affinity, specificity and cross-reactivity of IgE can fine-tune mast cell responses to allergens. The book also explores the beneficial roles of IgE antibodies in immunity to helminthes and protection against tumors, and how the properties of IgE-mediated immunity are employed in the development of IgE therapeutic antibodies. All chapters were written by respected experts in their fields and will appeal to scientists and clinicians alike. 410 0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v388 606 $aImmunospecificity 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aAllergy 606 $aParasitology 606 $aAdaptive Immunity 606 $aBiomedical Research 606 $aAllergology 606 $aParasitology 615 0$aImmunospecificity. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aAllergy. 615 0$aParasitology. 615 14$aAdaptive Immunity. 615 24$aBiomedical Research. 615 24$aAllergology. 615 24$aParasitology. 676 $a616.0795 702 $aLafaille$b Juan J$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aCurotto de Lafaille$b Maria A$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298272103321 996 $aIgE Antibodies: Generation and Function$92499272 997 $aUNINA