LEADER 03584nam  22007575  450 
001 9910298272103321
005 20230810184149.0
010   $a3-319-13725-5
024 7 $a10.1007/978-3-319-13725-4
035   $a(CKB)3710000000329733
035   $a(EBL)1966005
035   $a(OCoLC)900639416
035   $a(SSID)ssj0001424497
035   $a(PQKBManifestationID)11891907
035   $a(PQKBTitleCode)TC0001424497
035   $a(PQKBWorkID)11362919
035   $a(PQKB)10923311
035   $a(DE-He213)978-3-319-13725-4
035   $a(MiAaPQ)EBC1966005
035   $a(PPN)183520467
035   $a(EXLCZ)993710000000329733
100   $a20150102d2015      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aIgE Antibodies: Generation and Function /$fedited by Juan J. Lafaille, Maria A. Curotto de Lafaille
205   $a1st ed. 2015.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015.
215   $a1 online resource (157 p.)
225 1 $aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v388
300   $aDescription based upon print version of record.
311   $a3-319-13724-7 
320   $aIncludes bibliographical references and index.
327   $aBiology of IgE Production: IgE Cell Differentiation and the Memory of IgE Responses -- Molecular Mechanisms of IgE Class Switch Recombination -- Anti-IgE Therapy: Clinical Utility and Mechanistic Insights -- New Insights on the Signaling and Function of the High Affinity Receptor for IgE -- Helminth-Induced IgE and Protection Against Allergic Disorders -- IgE Immunotherapy Against Cancer.
330   $aThis volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites. It highlights the unique mechanisms involved in the regulation of IgE production at both the molecular and cellular level. Furthermore, it discusses in detail novel findings on how the affinity, specificity and cross-reactivity of IgE can fine-tune mast cell responses to allergens. The book also explores the beneficial roles of IgE antibodies in immunity to helminthes and protection against tumors, and how the properties of IgE-mediated immunity are employed in the development of IgE therapeutic antibodies. All chapters were written by respected experts in their fields and will appeal to scientists and clinicians alike.
410  0$aCurrent Topics in Microbiology and Immunology,$x2196-9965 ;$v388
606   $aImmunospecificity
606   $aMedicine$xResearch
606   $aBiology$xResearch
606   $aAllergy
606   $aParasitology
606   $aAdaptive Immunity
606   $aBiomedical Research
606   $aAllergology
606   $aParasitology
615  0$aImmunospecificity.
615  0$aMedicine$xResearch.
615  0$aBiology$xResearch.
615  0$aAllergy.
615  0$aParasitology.
615 14$aAdaptive Immunity.
615 24$aBiomedical Research.
615 24$aAllergology.
615 24$aParasitology.
676   $a616.0795
702   $aLafaille$b Juan J$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aCurotto de Lafaille$b Maria A$4edt$4http://id.loc.gov/vocabulary/relators/edt
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910298272103321
996   $aIgE Antibodies: Generation and Function$92499272
997   $aUNINA