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010   $a3-319-24663-1
024 7 $a10.1007/978-3-319-24663-5
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100   $a20151126d2015      u|             0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 14$aThe Development of Immunologic Competence$b[electronic resource] /$fby Domenico Ribatti
205   $a1st ed. 2015.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015.
215   $a1 online resource (65 p.)
300   $aDescription based upon print version of record.
311   $a3-319-24661-5 
320   $aIncludes bibliographical references and index.
327   $aPreface.- Introduction.- Human hematopoietic development.-The Bursa of Fabricius.- The Thymus.- Clinical correlates -- References -- Index.                      .
330   $aThis book traces significant aspects of the history of immunology, exploring the immune system and immunodeficiency. The author recounts human hematopoietic development, and how a distinction of the immune system into thymus-dependent and thymus-independent components has been demonstrated in different animal species, including amphibians, birds, and mammals. Other themes explored in this book include discoveries about the role of the thymus of the Bursa of Fabricius in the development of immunologic competence, and observations on the changes in the lymphoid organs after bursectomy and thymectomy in chickens. Readers will discover how the bursa provides a unique microenvironment for the proliferation and differentiation of B cells, while thymectomized and irradiated animals were deficient in lymphocytes that mediated inflammatory responses, as assessed by skin graft rejection, delayed-type hypersensitivity, and graft versus host reaction. A clear perspective for understanding several diseases and also the entire lymphoid system emerges through the experiments and extensive histopathological studies of patients with primary immunodeficiency diseases that are described in these chapters. Researchers in the life sciences, in biomedicine and the history of medicine will all find something of value in this highly engaging work. It will also appeal to those with an interest in public health and neurobiology.
606   $aMedicine
606   $aLife sciences
606   $aBiomedicine, general$3https://scigraph.springernature.com/ontologies/product-market-codes/B0000X
606   $aMedicine/Public Health, general$3https://scigraph.springernature.com/ontologies/product-market-codes/H00007
606   $aLife Sciences, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L00004
615  0$aMedicine.
615  0$aLife sciences.
615 14$aBiomedicine, general.
615 24$aMedicine/Public Health, general.
615 24$aLife Sciences, general.
676   $a610
700   $aRibatti$b Domenico$4aut$4http://id.loc.gov/vocabulary/relators/aut$0793065
906   $aBOOK
912   $a9910298270303321
996   $aThe Development of Immunologic Competence$92498349
997   $aUNINA