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024 7 $a10.1007/978-3-0348-0955-9
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035   $a(DE-He213)978-3-0348-0955-9
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100   $a20151125d2015      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aCirculating microRNAs in Disease Diagnostics and their Potential Biological Relevance /$fedited by Peter Igaz
205   $a1st ed. 2015.
210  1$aBasel :$cSpringer Basel :$cImprint: Springer,$d2015.
215   $a1 online resource (292 p.)
225 1 $aExperientia Supplementum,$x2504-3692 ;$v106
300   $aDescription based upon print version of record.
311 08$a3-0348-0953-0 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $aPart I: General features and technical issues related to circulating microRNA -- 1. Introduction to microRNAs: biogenesis, action, relevance of tissue microRNAs in disease pathogenesis, diagnosis and therapy. The concept of circulating microRNAs -- 2. Extracellular microRNAs in membrane vesicles and non-vesicular carriers -- 3. Technical aspects related to the analysis of circulating microRNAs -- Part II: Diagnostic relevance of circulating microRNAs -- 4. Circulating blood-borne microRNAs as biomarkers in solid tumors -- 5. Circulating microRNA as biomarkers in hematological malignancies -- 6 Circulating microRNAs as biomarkers in cardiovascular diseases -- 7 Circulating microRNAs in neurodegenerative diseases -- 8 Circulating extracellular microRNA in systemic autoimmunity -- 9. Circulating microRNAs in inflammatory bowel diseases -- 10. Circulating microRNAs in diabetes progression: discovery, validation and research translation -- 11. Diagnostic relevance of microRNAs in other body fluids including urine, feces and saliva -- Part III: Potential biological relevance of circulating microRNA -- 12 Circulating microRNAs as hormones ? intercellular and inter-organ conveyors of epigenetic information? -- 13. Are circulating microRNAs involved in tumor surveillance? -- 14.-Hypothetic interindividual and interspecies relevance of microRNAs released in body fluids.
330   $aMicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance.
410  0$aExperientia Supplementum,$x2504-3692 ;$v106
606   $aMolecular genetics
606   $aBiomaterials
606   $aNucleic acids
606   $aClinical biochemistry
606   $aMolecular Genetics
606   $aNucleic Acid
606   $aMedical Biochemistry
615  0$aMolecular genetics.
615  0$aBiomaterials.
615  0$aNucleic acids.
615  0$aClinical biochemistry.
615 14$aMolecular Genetics.
615 24$aNucleic Acid.
615 24$aMedical Biochemistry.
676   $a572.88
702   $aIgaz$b Peter$4edt$4http://id.loc.gov/vocabulary/relators/edt
801  0$bMiAaPQ
801  1$bMiAaPQ
801  2$bMiAaPQ
906   $aBOOK
912   $a9910298268103321
996   $aCirculating microRNAs in Disease Diagnostics and their Potential Biological Relevance$92524456
997   $aUNINA