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010   $a3-319-20098-4
024 7 $a10.1007/978-3-319-20098-9
035   $a(CKB)3710000000452054
035   $a(EBL)3567819
035   $a(SSID)ssj0001534850
035   $a(PQKBManifestationID)11824418
035   $a(PQKBTitleCode)TC0001534850
035   $a(PQKBWorkID)11498354
035   $a(PQKB)10085993
035   $a(DE-He213)978-3-319-20098-9
035   $a(MiAaPQ)EBC3567819
035   $a(PPN)187685533
035   $a(EXLCZ)993710000000452054
100   $a20150717d2015      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aSH Domains $eStructure, Mechanisms and Applications /$fedited by Natalya Kurochkina
205   $a1st ed. 2015.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015.
215   $a1 online resource (252 p.)
300   $aDescription based upon print version of record.
311   $a3-319-20097-6 
320   $aIncludes bibliographical references at the end of each chapters.
327   $aSH3 Domains as Suitable Models to Study Amyloid Aggregation -- SH Domain Proteins in Plants: Roles in Signaling Transduction and Membrane Trafficking -- Versatility of SH3 Domains in the Cellular Machinery -- Structure-Function Relationship of Bacterial SH3 Domains -- Activation of PI3K by Thyroid Hormone Nuclear Receptors -- SH Domains? Interaction with SliMs: Maximizing Adaptivity of Signaling Networks -- SH Domains and Epidermal Growth Factor Receptor -- SH2 Domain Structures and Interactions -- Cytoskeletal Signaling by Src Homology Domain-Containing Adaptor Proteins -- Structure and Function of Jak3- SH2 Domain -- Helical Assemblies and SH Domains.
330   $aThis book covers structure, function, and important roles of the SH domains, structure-function relationships, the versatile nature of their action, mechanisms of aggregation, specificity of interactions, impact of mutations on protein functional dysregulation, and cell signaling. Their involvement in various cellular processes such as migration, invasiveness, actin reorganization, shaping spines, determination of the morphology assembly of fibrils, and mechanotransduction makes these molecules attractive drug targets. Substrates, inhibitors and activators of PTKs present a wide variety of therapeutic agents in the context of delivering treatments for numerous pathologies. The new emerging field of stem cell therapies and design of biomaterials for treatments relies on the directed regulation of stem cell growth, differentiation and morphology, as well as the production of biomimetic scaffolds that respond to programmed signals. Advances in deciphering the mechanisms of action of these important molecules will lead to the implementation and success of their vital applications.
606   $aProteins
606   $aCytology
606   $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040
606   $aProtein Structure$3https://scigraph.springernature.com/ontologies/product-market-codes/L14050
606   $aProtein-Ligand Interactions$3https://scigraph.springernature.com/ontologies/product-market-codes/L14060
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
615  0$aProteins.
615  0$aCytology.
615 14$aProtein Science.
615 24$aProtein Structure.
615 24$aProtein-Ligand Interactions.
615 24$aCell Biology.
676   $a612.01516
702   $aKurochkina$b Natalya$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910298268003321
996   $aSH Domains$92529398
997   $aUNINA