LEADER 04711nam 22006975 450 001 9910298266603321 005 20200706171145.0 010 $a1-4939-3213-6 024 7 $a10.1007/978-1-4939-3213-9 035 $a(CKB)3710000000500657 035 $a(EBL)4081972 035 $a(SSID)ssj0001583899 035 $a(PQKBManifestationID)16264988 035 $a(PQKBTitleCode)TC0001583899 035 $a(PQKBWorkID)14864265 035 $a(PQKB)10440012 035 $a(DE-He213)978-1-4939-3213-9 035 $a(MiAaPQ)EBC4081972 035 $a(PPN)190527617 035 $a(EXLCZ)993710000000500657 100 $a20151102d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aSodium and Water Homeostasis $eComparative, Evolutionary and Genetic Models /$fedited by Kelly Anne Hyndman, Thomas L. Pannabecker 205 $a1st ed. 2015. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2015. 215 $a1 online resource (325 p.) 225 1 $aPhysiology in Health and Disease,$x2625-252X 300 $aDescription based upon print version of record. 311 $a1-4939-3212-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroduction -- ANG II and water balance in frogs -- Sex differences in ANGII hypertension -- Na-K-ATPase b subunit association with tight junction Drosophila tub size and tight junction function,- Na-K-ATPase in hypertension -- Endothelin regulation of ion transport in non-mammlian transporting epithelia -- Genetic models of Endothelin regulation of sodium transport -- miRNA and sodium and water balance in the developing zebrafish -- miRNA and sodiumand water balance in mammals -- Comparative and genetic models of WNK signaling in osmotic homeostasis -- Genetics of WNK signaling and disease in humans -- Comparative and evolutionary physiology of Water channels -- Genetic models resulting in urine concentrating defect -- Water balance in desert-adapted animals.0 Comparisons of nephron morphology and the urine concentrating mechanism -- Non-traditional models: the giraffe kidney -- Non-traditional models: insect tubule transport -- Circadian clock in ion transporters in insect vision -- Circadian clock, melatonin, and osmoregulation in fishes.  . 330 $aThis book presents cutting edge methods that provide insights into the pathways by which salt and water traverse cell membranes and flow in an orchestrated fashion amongst the many compartments of the body. It focuses on a number of molecular, cellular and whole animal studies that involve multiple physiological systems and shows how the internal milieu is regulated by multifactorial gene regulation, molecular signaling, and cell and organ architecture. Topics covered include: water channels, the urinary concentrating mechanism, angiotensin, the endothelin system, miRNAs and MicroRNA in osmoregulation, desert-adapted mammals, the giraffe kidney, mosquito Malpighian tubules, and circadian rhythms. The book highlights how different approaches to explaining the same physiological processes greatly increase our understanding of these fundamental processes. Greater integration of comparative, evolutionary and genetic animal models in basic science and medical science will improve our overall grasp of the mechanisms of sodium and water balance. 410 0$aPhysiology in Health and Disease,$x2625-252X 606 $aAnimal physiology 606 $aEvolutionary biology 606 $aHuman physiology 606 $aBiochemistry 606 $aAnimal Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33030 606 $aEvolutionary Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L21001 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aAnimal Biochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/L14013 615 0$aAnimal physiology. 615 0$aEvolutionary biology. 615 0$aHuman physiology. 615 0$aBiochemistry. 615 14$aAnimal Physiology. 615 24$aEvolutionary Biology. 615 24$aHuman Physiology. 615 24$aAnimal Biochemistry. 676 $a570 702 $aHyndman$b Kelly Anne$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aPannabecker$b Thomas L$4edt$4http://id.loc.gov/vocabulary/relators/edt 712 02$aAmerican Physiological Society. 906 $aBOOK 912 $a9910298266603321 996 $aSodium and Water Homeostasis$92500493 997 $aUNINA