LEADER 06014nam 22006855 450 001 9910298266103321 005 20250609111347.0 010 $a3-319-21702-X 024 7 $a10.1007/978-3-319-21702-4 035 $a(CKB)3710000000492460 035 $a(EBL)4178423 035 $a(SSID)ssj0001583780 035 $a(PQKBManifestationID)16263282 035 $a(PQKBTitleCode)TC0001583780 035 $a(PQKBWorkID)14864879 035 $a(PQKB)11738872 035 $a(DE-He213)978-3-319-21702-4 035 $a(MiAaPQ)EBC4178423 035 $a(PPN)190536276 035 $a(MiAaPQ)EBC6237267 035 $a(EXLCZ)993710000000492460 100 $a20151015d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aBiology in Stem Cell Niche /$fedited by Kursad Turksen 205 $a1st ed. 2015. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2015. 215 $a1 online resource (239 p.) 225 1 $aStem Cell Biology and Regenerative Medicine,$x2196-8985 300 $aDescription based upon print version of record. 311 08$a3-319-21701-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPreface; Contents; Editor and Contributors; 1 The Hematopoietic Stem Cell Niche: Cell-Cell Interactions and Quiescence; 1 Introduction; 2 Cell-Cell Interactions; 2.1 Endothelial Cells; 2.2 Mesenchymal-Derived Cells of the Hematopoietic Stem Cell Niche; 2.2.1 Chemokine Ligand 12 Expressing Cells; 2.2.2 Nestin Expressing Cells; 2.2.3 Osteoblasts; 2.2.4 Leptin-Receptor Expressing Cells; 2.2.5 CD146 Expressing Cells; 2.2.6 Bone Cartilage Stromal Progenitor Cells; 3 Other Niche Cells; 3.1 Megakaryocytes; 3.1.1 Non-myelinated Schwann Cells; 3.1.2 Monocytes/Macrophages 327 $a3.1.3 Sympathetic Nervous System4 Hematopoietic Stem Cell Niche Structure and Physiology; 4.1 Integrins; 4.2 Wnts; 4.3 Hypoxia; 4.4 Energetics; 5 Intrinsic Regulators of Cell Cycle; 6 Conclusions; Acknowledgments; References; 2 The Mammalian Limbal Stem Cell Niche: A Complex Interaction Between Cells, Growth Factors and Extracellular Matrix; 1 Introduction; 2 Defining the Limbus as the Residence Site for Corneal Stem Cells; 3 The Limbus: Its Structure and Composition; 3.1 Corneal Epithelial Stem Cells and Their Niche: Cells that Interact with the Limbal Stem Cell Reservoir 327 $a3.1.1 Epithelial Cells3.1.2 Melanocytes; 3.1.3 Langerhans' Cells; 3.1.4 Stromal Cells; 3.1.5 Corneal Innervation; 3.2 Corneal Epithelial Stem Cells and Their Niche: Basal Membrane and Extracellular Matrix Components; 3.3 Corneal Epithelial Stem Cells and Their Niche: Growth Factors and Cytokines; 4 The Niche as Regulator of Limbal Stem Cells; 5 Corneal Epithelial Stem Cells: Renewal and Wound Healing; 6 Limbal Stem Cells and Therapy; 7 Conclusion; Acknowledgements; References; 3 Emerging Engineering Strategies for Studying the Stem Cell Niche; 1 Introduction; 2 Stem Cells and Their Niches 327 $a3 Stem Cell-ECM Interactions3.1 Stem Cell Adhesion to Niche ECM via Integrins; 3.2 Cadherins, Another Class of Adhesion Receptors; 3.3 Molecular Sequestering of Growth Factors and Cytokines by ECM; 4 Seminal Engineering Strategies---Establishing a Foundation; 4.1 Micro/Nanofabrication Techniques for Generating Pre-Printed Topographies; 4.2 Micropatterning Techniques to Relate Stem Cell Shape to Behavior; 4.3 Soft Matter Hydrogel Systems with Predefined Characteristics; 5 Second Generation Engineering Strategies---Increased Complexity with a Focus on Spatiotemporal Control 327 $a5.1 Biomaterials with Tunable Properties5.2 Spatiotemporal Control over Topography; 5.3 Spatiotemporal Control over Matrix Stiffness; 5.4 Dynamic Control of Integrin-Based Focal Adhesions; 6 Dissecting Cell-Cell Interactions within the Stem Cell Niche; 7 Early Approaches for Studying Stem Cell-Niche Cell Interactions In Vitro; 7.1 Patterned Bulk Stem Cell Co-Cultures; 7.2 Patterned 3D Stem Cell Co-Cultures; 8 Shifting Focus to Single-Cell Resolution and Artificial Niches; 8.1 Microfluidic Approaches for Single-Cell Co-Cultures; 8.2 Artificial Stem Cell-Niche Cell Signaling Approaches 327 $a9 Conclusions and Future Directions 330 $aThis comprehensive volume explores functions, pathologies, and applications of stem cells in relation to the niches in which they develop. Ten chapters cover the subject in depth, from a historical perspective through signaling, hormonal control, quiescence, biomimetics, epigenetics, engineering strategies for emulating, tumorigenesis and more. The chapter authors represent a broad range of international expertise and perspectives. This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Biology of Stem Cell Niche is an ideal complementary volume to Tissue-Specific Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them. 410 0$aStem Cell Biology and Regenerative Medicine,$x2196-8985 606 $aStem cells 606 $aBiomedical engineering 606 $aStem Cells$3https://scigraph.springernature.com/ontologies/product-market-codes/L16010 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 615 0$aStem cells. 615 0$aBiomedical engineering. 615 14$aStem Cells. 615 24$aBiomedical Engineering and Bioengineering. 676 $a616.02774 702 $aTurksen$b Kursad$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298266103321 996 $aBiology in Stem Cell Niche$92526749 997 $aUNINA