LEADER 04500nam 22005535 450 001 9910298265803321 005 20200705002321.0 010 $a1-4939-2904-6 024 7 $a10.1007/978-1-4939-2904-7 035 $a(CKB)3710000000466348 035 $a(EBL)4178107 035 $a(SSID)ssj0001546527 035 $a(PQKBManifestationID)16141203 035 $a(PQKBTitleCode)TC0001546527 035 $a(PQKBWorkID)14796115 035 $a(PQKB)11755691 035 $a(DE-He213)978-1-4939-2904-7 035 $a(MiAaPQ)EBC4178107 035 $a(PPN)188457240 035 $a(EXLCZ)993710000000466348 100 $a20150821d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 14$aThe Cytoskeleton in Health and Disease$b[electronic resource] /$fedited by Heide Schatten 205 $a1st ed. 2015. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2015. 215 $a1 online resource (395 p.) 300 $aDescription based upon print version of record. 311 $a1-4939-2903-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aPart 1. Overview of the Cytoskeleton -- Brief Overview of the Cytoskeleton -- Part 2. Focus on Cytoskeletal Interactions -- Cytoskeleton Dynamics in Health and Disease: Role of Molecular Switches and Rheostats -- Regulation of Cytoskeleton by the Rho Family of GTPases in Hematopoietic Stem Cells in Health and Disease -- The Role of the Cytoskeleton in Cell Migration, Its Influence on Stem Cells and the Special Role of GFAP in Glial Functions -- Centrosome-Microtubule Interactions in Health, Disease, and Disorders -- Cytoskeletal Elements and Reproductive Success in Animals -- Part 3. Focus on Microtubules -- Cytoskeleton and Regulation of Mitochondrial Translocation in Mammalian Eggs -- Tubulin Detyrosination in Epithelial Cells -- Mutations in Adenomatous Polyposis Coli, Their Role in Cytoskeletal Dynamics and Cancer Onset -- Small GTPases Act as Cellular Switches in the Context of Cilia -- Part 4. Focus on Intermediate Filaments -- Desmin Plays Dual Structural and Regulatory Functions Through Its Interaction with Partners in Muscle -- Desmin Filaments and Desmin-Related Myopathy -- Possible Functions of Intermediate Filaments in Mammalian Ovarian Follicles and Oocytes -- Part 5. Focus on Microfilaments -- Actin Organizing Proteins in Regulation of Osteoclast Function -- The Role of Drebrin-Binding Stable Actin Filaments in Dendritic Spine Morphogenesis -- The Role of the Actin Cytoskeleton in Cancer and Its Potential Use as a Therapeutic Target. 330 $aThis volume explores the cytoskeleton, examining its structural and functional roles and its dysfunctions which often lead to disease. Microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems are thoroughly discussed. The text is organized into four sections, each of which covers specific subtopics. These consist of an introductory chapter followed by topics of current interest and expert-provided contributions which include each topic's key cell and molecular details. Comprehensive yet concise,  The Cytoskeleton in Health and Disease presents cutting- edge new knowledge balanced with background information, both of which are readily understandable for the newcomer and for the experienced researcher alike. The book highlights the new aspects of the research and its impact on  the design of new strategies or the identification of new targets for therapeutic intervention. This book will be essential reading for scientists, students, teachers who are interested in expanding their knowledge related to the cytoskeleton for diagnostic, therapeutic or research-based purposes. 606 $aCell physiology 606 $aCell cycle 606 $aCell Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33010 606 $aCell Cycle Analysis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16030 615 0$aCell physiology. 615 0$aCell cycle. 615 14$aCell Physiology. 615 24$aCell Cycle Analysis. 676 $a570 702 $aSchatten$b Heide$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910298265803321 996 $aThe Cytoskeleton in Health and Disease$92503006 997 $aUNINA