LEADER 04911nam 22007215 450 001 9910298264003321 005 20200706015135.0 010 $a94-017-7197-9 024 7 $a10.1007/978-94-017-7197-9 035 $a(CKB)3710000000454041 035 $a(EBL)3567941 035 $a(SSID)ssj0001534792 035 $a(PQKBManifestationID)11995416 035 $a(PQKBTitleCode)TC0001534792 035 $a(PQKBWorkID)11497722 035 $a(PQKB)11753140 035 $a(DE-He213)978-94-017-7197-9 035 $a(MiAaPQ)EBC3567941 035 $a(PPN)187689776 035 $a(EXLCZ)993710000000454041 100 $a20150728d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aNeuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP) /$fedited by Caroline Fonta, László Négyessy 205 $a1st ed. 2015. 210 1$aDordrecht :$cSpringer Netherlands :$cImprint: Springer,$d2015. 215 $a1 online resource (401 p.) 225 1 $aSubcellular Biochemistry,$x0306-0225 ;$v76 300 $aDescription based upon print version of record. 311 $a94-017-7196-0 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $a1 Clinical forms and animal models of hypophosphatasia -- 2 Molecular genetics of hypophosphatasia and phenotype-genotype correlations -- 3 Genetically modified mice for studying TNAP function -- 4 Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis -- 5 Rediscovering TNAP in the brain: a major role in regulating the function and development of the cerebral cortex -- 6 TNAP in the retina -- 7 Tissue Non-specific Alkaline Phosphatase (TNAP) in vessels of the brain -- 8 What can we learn about the neural functions of TNAP from studies on other organs and tissues? -- 9 TNAP, an essential player in membrane lipid rafts of neuronal cells -- 10 Signal transduction pathways of TNAP: molecular network analyses -- 11 Vitamin B-6 Metabolism and Interactions with TNAP -- 12 Tetramisole and levamisole suppress neuronal activity independently from their inhibitory action on Tissue Non-Specific Alkaline Phosphatase in mouse cortex -- 13 TNAP and Pain Control -- 14 Neurological symptoms of Hypophosphatasia -- 15 Recombinant enzyme replacement therapy in hypophosphatasia -- 16 Neurogenetic Aspects of Hyperphosphatasia in Mabry Syndrome -- 17 The role of tissue non-specific alkaline phosphatase (TNAP) in Neurodegenerative diseases: Alzheimer?s disease in the focus -- 18 TNAP plays a key role in neural differentiation as well as in neurodegenerative disorders -- Index. 330 $aPhosphatases such as TNAP are fundamental in regulating cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. The proposed book aims to provide an overview of our current understanding of the functions of TNAP in the brain. 410 0$aSubcellular Biochemistry,$x0306-0225 ;$v76 606 $aHuman physiology 606 $aAnimal physiology 606 $aDevelopmental biology 606 $aNeurosciences 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 606 $aAnimal Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/L33030 606 $aDevelopmental Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L18000 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 615 0$aHuman physiology. 615 0$aAnimal physiology. 615 0$aDevelopmental biology. 615 0$aNeurosciences. 615 14$aHuman Physiology. 615 24$aAnimal Physiology. 615 24$aDevelopmental Biology. 615 24$aNeurosciences. 676 $a574.19253 702 $aFonta$b Caroline$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aNégyessy$b László$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298264003321 996 $aNeuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)$92538502 997 $aUNINA