LEADER 04175nam 22006735 450 001 9910298263403321 005 20200704232951.0 010 $a1-4939-2895-3 024 7 $a10.1007/978-1-4939-2895-8 035 $a(CKB)3710000000454031 035 $a(EBL)3567916 035 $a(SSID)ssj0001534709 035 $a(PQKBManifestationID)11820809 035 $a(PQKBTitleCode)TC0001534709 035 $a(PQKBWorkID)11513903 035 $a(PQKB)10665578 035 $a(DE-He213)978-1-4939-2895-8 035 $a(MiAaPQ)EBC3567916 035 $a(PPN)187689482 035 $a(EXLCZ)993710000000454031 100 $a20150727d2015 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aGlucocorticoid Signaling $eFrom Molecules to Mice to Man /$fedited by Jen-Chywan Wang, Charles Harris 205 $a1st ed. 2015. 210 1$aNew York, NY :$cSpringer New York :$cImprint: Springer,$d2015. 215 $a1 online resource (387 p.) 225 1 $aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v872 300 $aDescription based upon print version of record. 311 $a1-4939-2894-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aSection I: Introductory Materials -- Regulatory actions of glucocorticoid hormones: from organisms to mechanisms.-  Molecular Biology of  Glucocorticoid Signaling.-Mechanisms of Glucocorticoid-regulated Gene Transcription -- Clinical Perspective: What do Addison and Cushing tell us about Glucocorticoid Action? -- Section II: Effects of Glucocorticoids in Metabolism -- Regulation of Glucose Homeostasis by Glucocorticoids -- How do Glucocorticoids Regulate Lipid Metabolism? -- Glucocorticoids and Skeletal Muscle -- Section III: Specific Effects of Glucocorticoids on Tissues -- Glucocorticoid- induced osteoporosis -- Effects of Glucocorticoids on Immune System -- Glucocorticoids and the brain: neural mechanisms regulating the stress response -- Glucocorticoid Regulation of Reproduction -- Glucocorticoids and the lung -- Glucocorticoids and the Cardiovascular System -- Glucocorticoids and Cancer -- Section IV: Miscellaneous Topics -- Animal Models of Altered Glucocorticoid Signaling -- The Dehydrogenase Hypothesis -- Conclusions and Future Directions. 330 $aThis timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians. 410 0$aAdvances in Experimental Medicine and Biology,$x0065-2598 ;$v872 606 $aBiochemistry 606 $aEndocrinology 606 $aHuman physiology 606 $aBiochemistry, general$3https://scigraph.springernature.com/ontologies/product-market-codes/L14005 606 $aEndocrinology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33053 606 $aHuman Physiology$3https://scigraph.springernature.com/ontologies/product-market-codes/B13004 615 0$aBiochemistry. 615 0$aEndocrinology. 615 0$aHuman physiology. 615 14$aBiochemistry, general. 615 24$aEndocrinology. 615 24$aHuman Physiology. 676 $a612.405 702 $aWang$b Jen-Chywan$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHarris$b Charles$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910298263403321 996 $aGlucocorticoid Signaling$92513392 997 $aUNINA