LEADER 05125nam 2200469 450 001 9910297402703321 005 20211119054552.0 010 $a0-12-802787-8 010 $a0-12-802761-4 035 $a(CKB)4100000000589551 035 $a(MiAaPQ)EBC5090267 035 $a(PPN)228033640 035 $a(EXLCZ)994100000000589551 100 $a20171019h20182018 uy 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 00$aMolecular pathology $ethe molecular basis of human disease /$fedited by William B. Coleman, Gregory J. Tsongalis 205 $aSecond edition. 210 1$aLondon, United Kingdom :$cAcademic Press, an imprint of Elsevier,$d[2018] 210 4$dİ2018 215 $a1 online resource $cillustrations (some color) 320 $aIncludes bibliographical references and index. 327 $a1 - Molecular Mechanisms of Cell Death -- 2 - Acute and Chronic Inflammation Induces Disease Pathogenesis -- 3 - Infection and Host Response -- 4 ? Neoplasia -- 5 - Basic Concepts in Human Molecular Genetics -- 6 - The Human Genome: Understanding Human Disease in the Post-Genomic Era -- 7 - The Human Transcriptome: Implications for Understanding, Diagnosing, and Treating Human Disease -- 8 - The Human Epigenome?Implications for the Understanding of Human Disease -- 9 - Clinical Proteomics and Molecular Pathology -- 10 - Integrative Systems Biology -- 11 - Pathology: The Clinical Description of Human Disease -- 12 - Understanding Molecular Pathogenesis: The Biological Basis of Human Disease and Implications for Improved Treatment of Human Disease -- 13 - Integration of Molecular and Cellular Pathogenesis: A Bioinformatics Approach -- 14 - Molecular Basis of Cardiovascular Disease -- 15 - Molecular Basis of Hemostatic and Thrombotic Diseases -- 16 - Molecular Basis of Lymphoid and Myeloid Diseases -- 17 - Molecular Basis of Diseases of Immunity -- 18 - Molecular Basis of Pulmonary Disease -- 19 - Molecular Basis of Diseases of the Gastrointestinal Tract -- 20 - Molecular Basis of Liver Disease -- 21 - Molecular Basis of Diseases of the Exocrine Pancreas -- 22 - Molecular Basis of Diseases of the Endocrine System -- 23 - Molecular Basis of Gynecologic Diseases -- 24 - Molecular Basis of Kidney Disease -- 25 - Molecular Pathogenesis of Prostate Cancer -- 26 - Molecular Biology of Breast Cancer -- 27 - Molecular Basis of Skin Disease -- 28 - Molecular Basis of Bone Diseases -- 29 - Molecular Basis of Diseases of the Nervous System -- 30 - Molecular Diagnosis of Human Disease -- 31 - Molecular Assessment of Human Diseases in the Clinical Laboratory -- 32 - Pharmacogenomics and Personalized Medicine in the Treatment of Human Diseases 330 $aAs the molecular basis of human disease becomes better characterized, and the implications for understanding the molecular basis of disease becomes realized through improved diagnostics and treatment, Molecular Pathology, Second Edition stands out as the most comprehensive textbook where molecular mechanisms represent the focus. It is uniquely concerned with the molecular basis of major human diseases and disease processes, presented in the context of traditional pathology, with implications for translational molecular medicine. The Second Edition of Molecular Pathology has been thoroughly updated to reflect seven years of exponential changes in the fields of genetics, molecular, and cell biology which molecular pathology translates in the practice of molecular medicine. The textbook is intended to serve as a multi-use textbook that would be appropriate as a classroom teaching tool for biomedical graduate students, medical students, allied health students, and others (such as advanced undergraduates). Further, this textbook will be valuable for pathology residents and other postdoctoral fellows that desire to advance their understanding of molecular mechanisms of disease beyond what they learned in medical/graduate school. In addition, this textbook is useful as a reference book for practicing basic scientists and physician scientists that perform disease-related basic science and translational research, who require a ready information resource on the molecular basis of various human diseases and disease states. Explores the principles and practice of molecular pathology: molecular pathogenesis, molecular mechanisms of disease, and how the molecular pathogenesis of disease parallels the evolution of the disease. Explains the practice of "molecular medicine" and the translational aspects of molecular pathology Teaches from the perspective of "integrative systems biology". 606 $aPathology, Molecular 606 $aMolecular biology 615 0$aPathology, Molecular. 615 0$aMolecular biology. 676 $a571.94 702 $aColeman$b William B. 702 $aTsongalis$b Gregory J. 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 801 2$bQCQU 906 $aBOOK 912 $a9910297402703321 996 $aMolecular pathology$91897748 997 $aUNINA