LEADER 04507 am 22007093u 450 001 9910293139603321 005 20230125204625.0 010 $a981-10-8488-2 024 7 $a10.1007/978-981-10-8488-1 035 $a(CKB)4100000003359767 035 $a(DE-He213)978-981-10-8488-1 035 $a(MiAaPQ)EBC5578425 035 $a(Au-PeEL)EBL5578425 035 $a(OCoLC)1030963204 035 $a(MiAaPQ)EBC6422622 035 $a(Au-PeEL)EBL6422622 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/60592 035 $a(PPN)226694968 035 $a(EXLCZ)994100000003359767 100 $a20180404d2018 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aNicotinic Acetylcholine Receptor Signaling in Neuroprotection$b[electronic resource] /$fedited by Akinori Akaike, Shun Shimohama, Yoshimi Misu 205 $a1st ed. 2018. 210 $cSpringer Nature$d2018 210 1$aSingapore :$cSpringer Singapore :$cImprint: Springer,$d2018. 215 $a1 online resource (X, 191 p. 62 illus., 20 illus. in color.) 311 $a981-10-8487-4 327 $a1.Overview -- 2.In vivo imaging of nicotinic acetylcholine receptors in the central nervous system -- 3.A new aspect of cholinergic transmission in the central nervous system -- 4.Nicotinic acetylcholine receptor signaling: roles in neuroprotection -- 5.Regulation by nicotinic acetylcholine receptors of microglial glutamate transporters: role of microglia in neuroprotection -- 6.Shati/Nat8l and N-acetylaspartate (NAA) have important roles in regulating nicotinic acetylcholine receptors in neuronal and psychiatric diseases in animal models and humans -- 7.Nicotinic acetylcholine receptors in regulation of pathology of cerebrovascular disorders -- 8.Roles of nicotinic acetylcholine receptors in the pathology and treatment of Alzheimer?s and Parkinson?s diseases -- 9.SAK3-induced neuroprotection is mediated by nicotinic acetylcholine receptors -- 10.Removal of blood amyloid as a therapeutic strategy for Alzheimer?s disease: the influence of smoking and nicotine. 330 $aThis open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases. Accumulating evidence suggests that nAChRs in the CNS play important roles not only in excitatory neurotransmission but also in neuronal survival and related functions. Neuroprotection mediated by nAChRs in neurodegenerative diseases such as Alzheimer's disease is the major topic of this book. In response to rapidly evolving areas in clinical and laboratory neuropharmacology and neurochemistry, this volume provides in-depth coverage of neuroprotection in basic research and future developments in the clinical application of effective neuroprotective strategies in neurodegenerative diseases. This work appeals to both basic and clinical researchers in several fields, such as neuroscience, neurology, and pharmacology. This book is published with open access under a CC BY 4.0 license. 606 $aNeurosciences 606 $aNeurology  606 $aPharmacology 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 606 $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001 606 $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007 610 $aAlzheimer?s disease 610 $aNeurodegenerative diseases 610 $aGlia 610 $aTransporter 610 $aNicotine 615 0$aNeurosciences. 615 0$aNeurology . 615 0$aPharmacology. 615 14$aNeurosciences. 615 24$aNeurology. 615 24$aPharmacology/Toxicology. 676 $a612.8 700 $aAkinori Akaike$4auth$01355850 702 $aAkaike$b Akinori$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aShimohama$b Shun$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMisu$b Yoshimi$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910293139603321 996 $aNicotinic Acetylcholine Receptor Signaling in Neuroprotection$93359928 997 $aUNINA