LEADER 01011nam a22002771i 4500 001 991003468039707536 005 20031016153811.0 008 031111s1970 uik|||||||||||||||||eng 020 $a0582528062 035 $ab12430857-39ule_inst 035 $aARCHE-046414$9ExL 040 $aDip.to Lingue$bita$cA.t.i. Arché s.c.r.l. Pandora Sicilia s.r.l. 082 04$a843.8 100 1 $aVerne, Jules$0202108 245 10$aRound the world in eighty days /$cby Jues Verne ; translated and abridged by H. E. Palmer, D. Litt 260 $aLondon :$bLongman,$c1970 300 $a1 v. ;$c19 cm 440 0$aLongman simplified english series 700 1 $aLitt, D. 700 1 $aPalmer, Henry Emerson 907 $a.b12430857$b02-04-14$c13-11-03 912 $a991003468039707536 945 $aLE012 D 116$g1$i2012000069695$lle012$o-$pE0.00$q-$rl$s- $t0$u1$v1$w1$x0$y.i12854980$z13-11-03 996 $aRound the world in eighty days$9166842 997 $aUNISALENTO 998 $ale012$b13-11-03$cm$da $e-$feng$guik$h0$i1 LEADER 03342nam 2200517z- 450 001 9910345964003321 005 20210212 035 $a(CKB)4920000000094074 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58603 035 $a(oapen)doab58603 035 $a(EXLCZ)994920000000094074 100 $a20202102d2018 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aRole of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function 210 $cFrontiers Media SA$d2018 215 $a1 online resource (152 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-385-5 330 $aGenetic variations may change the structure and function of individual proteins as well as affect their interactions with other proteins and thereby impact metabolic processes dependent on protein-protein interactions. For example, cytochrome P450 proteins, which metabolize a vast array of drugs, steroids and other xenobiotics, are dependent on interactions with redox and allosteric partner proteins for their localization, stability, (catalytic) function and metabolic diversity (reactions). Genetic variations may impact such interactions by changing the splicing and/or amino acid sequence which in turn may impact protein topology, localization, post translational modifications and three dimensional structure. More generally, research on single gene defects and their role in disease, as well as recent large scale sequencing studies suggest that a large number of genetic variations may contribute to disease not only by affecting gene function or expression but also by modulating complex protein interaction networks.The aim of this research topic is to bring together researchers working in the area of drug, steroid and xenobiotic metabolism who are studying protein-protein interactions, to describe their recent advances in the field. We are aiming for a comprehensive analysis of the subject from different approaches including genetics, proteomics, transcriptomics, structural biology, biochemistry and pharmacology. Of particular interest are papers dealing with translational research describing the role of novel genetic variations altering protein-protein interaction. 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Henderson$4auth 702 $aYuji Ishii$4auth 906 $aBOOK 912 $a9910345964003321 996 $aRole of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function$93018404 997 $aUNINA LEADER 02997oas 2201153 a 450 001 9910285058903321 005 20251106213014.0 035 $a(DE-599)ZDB2140127-5 035 $a(DE-599)2831915-1 035 $a(DE-599)2140127-5 035 $a(OCoLC)49502199 035 $a(CONSER) 2002211449 035 $a(CKB)991042728132006 035 $a(EXLCZ)99991042728132006 100 $a20020402b20002014 uy a 101 0 $aeng 135 $aur||||||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 04$aThe behavior analyst today 210 1$aPhiladelphia, PA :$cJ.D. 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