LEADER 00647nam0-2200229 --450 001 9910274359303321 005 20180622124313.0 100 $a20180622d1971----kmuy0itay5050 ba 101 0 $aeng 102 $aGB 105 $a 001yy 200 1 $aNew techniques of architectural rendering$fHelmut Jacoby 210 $aLondon$cThames & Hudson$d1971 215 $a143 p.$cill.$d23x29 cm 700 1$aJacoby,$bHelmut$024852 801 0$aIT$bUNINA$gREICAT$2UNIMARC 901 $aBK 912 $a9910274359303321 952 $aRGT 1265$b4320$fDARPU 959 $aDARPU 996 $aNew techniques of architectural rendering$91509803 997 $aUNINA LEADER 03267nam 2200409z- 450 001 9910220037703321 005 20210211 035 $a(CKB)3800000000216400 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/43079 035 $a(oapen)doab43079 035 $a(EXLCZ)993800000000216400 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aChemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches 210 $cFrontiers Media SA$d2017 215 $a1 online resource (153 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-172-0 330 $aMounting evidence shows that increasing numbers of children are being diagnosed with neurodevelopmental disorders, and it is clear that this increase cannot be explained by genetic background alone. A number of studies, including epidemiological studies, have found an association between in-utero and childhood exposure to certain chemicals, such as endocrine disruptors, psychoactive pharmaceuticals, volatile organic chemicals, persistent organic compounds and heavy metals, and children's brain development. Yet, the mechanisms by which these chemicals impair brain development and function are not fully understood. In addition, little is known about how these chemicals enter and accumulate in the brain. Experimental approaches are essential to understand how those harmful chemicals enter children's brain and pose discrete effects on specific brain sites. These approaches include the following: improvement of technologies for the detection and measurement of neuroendocrinological and behavioral changes in animal models: development of analytical methods for the identification and quantification of chemicals and their metabolites in the brain; development of in vitro cell line assays; and imaging technologies to illustrate cellular functions. In this research topic, we collected articles that provide state-of-the-art science and technologies that can help us identify environmental chemicals that influence brain development. We also included articles that lead to a better understanding of the actions and dynamics of these chemicals. The articles in this research topics supplied novel information about harmful endpoints of environmental chemicals. The reviews demonstrated the typical and novel interactions between environmental chemicals and the developing brain. We believe that these studies would lead to further understanding of neurodevelopmental disorders caused by environmental factors. 517 $aChemicals in the Environment and Brain Development 610 $aBrain Development 610 $achemicals 610 $aChildren's health 610 $adevelopmental disorder 610 $aEndocrine-disrupting chemicals 610 $aenvironment 700 $aShoji F. Nakayama$4auth$01303431 702 $aFumihiko Maekawa$4auth 702 $aKazuaki Nakamura$4auth 906 $aBOOK 912 $a9910220037703321 996 $aChemicals in the Environment and Brain Development: Importance of Neuroendocrinological Approaches$93027035 997 $aUNINA