LEADER 04427nam 22007095 450 001 9910845489803321 005 20250808093347.0 010 $a9783031550225 010 $a3031550226 024 7 $a10.1007/978-3-031-55022-5 035 $a(MiAaPQ)EBC31230582 035 $a(Au-PeEL)EBL31230582 035 $a(DE-He213)978-3-031-55022-5 035 $a(CKB)31120757800041 035 $a(OCoLC)1428259932 035 $a(MiAaPQ)EBC31574236 035 $a(Au-PeEL)EBL31574236 035 $a(EXLCZ)9931120757800041 100 $a20240326d2024 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aCellular and Molecular Aspects of Ageing /$fedited by Valquiria Bueno 205 $a1st ed. 2024. 210 1$aCham :$cSpringer Nature Switzerland :$cImprint: Springer,$d2024. 215 $a1 online resource (159 pages) 311 08$a9783031550218 311 08$a3031550218 320 $aIncludes bibliographical references. 327 $a1. Introduction: Daniela Frasca & Valquiria Bueno -- 2. Cellular Senescence: Laura Haynes -- 3. Genomic instability: Carlos López-Otín -- 4. Telomeres:Rodrigo do Tocantins C.S.Rodrigues -- 5. Epigenetic: Miriam Galvonas Jasiulionis -- 6. Proteostasis: Ana Maria Cuervo -- 7. Deregulated nutrient-sensing: Pedro Manoel M.M.Vieira -- 8. Mitochondria/Oxidative Stress: Tiago Rodrigues -- 9. Stem cell exhaustion: Michael D Milsom -- 10. Cell-to-cell communication: Ana O'Loghlen -- 11. Senescence-associated secretory phenotype (SASP): Janet M Lord. 330 $aEven though life expectancy increased in the last decades, ageing has been considered a strong risk factor for age-related diseases, disability and death. The further understanding of cellular and molecular aspects of ageing could predict the onset of diseases in advance, prevent functional decline and identify targets for interventions focused in healthy ageing. The hypothesis that organismal ageing and dysfunction is influenced by the accumulation of senescent cells had origin in Hayflick and Moorhead results from cultured human fibroblasts. It was shown that fibroblasts presented a limited capacity for proliferation reaching thus the state of irreversible growth arrest (replicative senescence). In 2011, van Deusen et al. showed that p16Ink4a accumulation was associated with premature ageing in a mouse model and the inactivation of the p16Ink4a gene mitigated the ageing phenotype. Thus, the cell cycle arrest due to the expression of p16Ink4a and p21CIP (cell cycle inhibitors) is the main characteristic of senescence. In addition to cellular senescence, the hallmarks of ageing include genomic instability, telomere shortening , epigenetic alterations, loss of proteostasis, deregulated nutrient-sensing, mitochondrial dysfunction, stem cell exhaustion, altered intercellular communication, and a pro-inflammatory senescence-associated secretory phenotype (SASP). In this book, researchers will comprehensively discuss relevant changes occurring at cellular and molecular levels (human and animal models) based on the hallmarks of ageing. The impact of lifestyle and benefits of physical activity and nutrition will be also discussed. Unravelling cellular and molecular aspects of ageing is crucial for the unanswered questions about ageing and for guiding interventions such as changes in lifestyle, senolytic (kills senescent cells), and senomorphic (interrupts deleterious intercellular communication) therapies. 606 $aMolecular biology 606 $aCytology 606 $aGenetics 606 $aImmunology 606 $aMedical sciences 606 $aMolecular Biology 606 $aCell Biology 606 $aGenetics and Genomics 606 $aImmunology 606 $aHealth Sciences 615 0$aMolecular biology. 615 0$aCytology. 615 0$aGenetics. 615 0$aImmunology. 615 0$aMedical sciences. 615 14$aMolecular Biology. 615 24$aCell Biology. 615 24$aGenetics and Genomics. 615 24$aImmunology. 615 24$aHealth Sciences. 676 $a612.67 702 $aBueno$b Valquiria 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910845489803321 996 $aCellular and Molecular Aspects of Ageing$94430289 997 $aUNINA LEADER 02253oas 2200829 a 450 001 9910263056003321 005 20260127110518.0 011 $a1753-8971 035 $a(DE-599)ZDB2415170-1 035 $a(OCoLC)154679158 035 $a(CONSER) 2007213204 035 $a(CKB)1000000000280444 035 $a(DE-599)2415170-1 035 $a(EXLCZ)991000000000280444 100 $a20070712a20089999 uy a 101 0 $aeng 135 $aurcnu|||||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aChina economic journal 210 $aAbingdon $cTaylor and Francis$d2008- 300 $aRefereed/Peer-reviewed 311 08$a1753-8963 606 $aEconomic history$2fast$3(OCoLC)fst00901974 606 $aEconomic policy$2fast$3(OCoLC)fst00902025 606 $aVolkswirtschaft$2stw 606 $aWirtschaftslage$2stw 606 $aWirtschaftswissenschaft$2stw 606 $aChina$2stw 607 $aChina$xEconomic conditions$y2000-$vPeriodicals 607 $aChina$xEconomic policy$y2000-$vPeriodicals 607 $aChine$xConditions e?conomiques$y2000-$vPe?riodiques 607 $aChine$xPolitique e?conomique$y2000-$vPe?riodiques 607 $aChina$2fast$1https://id.oclc.org/worldcat/entity/E39PBJcrd4RjtCBk4wfMhTwwG3 608 $aPeriodicals.$2fast 608 $aPeriodicals.$2lcgft 610 $aEconomic History 615 7$aEconomic history. 615 7$aEconomic policy. 615 7$aVolkswirtschaft. 615 7$aWirtschaftslage. 615 7$aWirtschaftswissenschaft. 615 7$aChina. 676 $a382 712 02$aZhongguo jing ji yan jiu zhong xin. 801 0$bNSD 801 1$bNSD 801 2$bOCLCS 801 2$bWAU 801 2$bDLC 801 2$bOCLCQ 801 2$bOCLCF 801 2$bOCLCQ 801 2$bNLE 801 2$bDLC 801 2$bAU@ 801 2$bUKMGB 801 2$bBWN 801 2$bS2H 801 2$bOCLCO 801 2$bOCLCQ 801 2$bU3W 801 2$bOCLCL 801 2$bOCLCQ 801 2$bUAB 801 2$bUEJ 801 2$bOCLCL 906 $aJOURNAL 912 $a9910263056003321 996 $aChina economic journal$91935733 997 $aUNINA