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035   $a(CKB)4100000002484633
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/58232
035   $a(EXLCZ)994100000002484633
100   $a20202102d2016      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aRepetitive Structures in Biological Sequences: Algorithms and Applications
210   $cFrontiers Media SA$d2016
215   $a1 electronic resource (93 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-018-X 
330   $aRepetitive structures in biological sequences are emerging as an active focus of research and the unifying concept of "repeatome" (the ensemble of knowledge associated with repeating structures in genomic/proteomic sequences) has been recently proposed in order to highlight several converging trends. One main trend is the ongoing discovery that genomic repetitions are linked to many biological significant events and functions. Diseases (e.g. Huntington's disease) have been causally linked with abnormal expansion of certain repeating sequences in the human genome. Deletions or multiple copy duplications of genes (Copy Number Variations) are important in the aetiology of cancer, Alzheimer, and Parkinson diseases. A second converging trend has been the emergence of many different models and algorithms for detecting non-obvious repeating patterns in strings with applications to in genomic data. Borrowing methodologies from combinatorial pattern, matching, string algorithms, data structures, data mining and machine learning these new approaches break the limitations of the current approaches and offer a new way to design better trans-disciplinary research. The articles collected in this book provides a glance into the rich emerging area of repeatome research, addressing some of its pressing challenges. We believe that these contributions are valuable resources for repeatome research and will stimulate further research from bioinformatic, statistical, and biological points of view.
517   $aRepetitive Structures in Biological Sequences
610   $aAlgorithms
610   $aRepetitive structures
610   $anext generation sequencing
610   $atandem repeats
610   $atransposable elements
700   $aMarco Pellegrini$4auth$0500114
702   $aAlberto Magi$4auth
702   $aCostas S. Iliopoulos$4auth
906   $aBOOK
912   $a9910261145903321
996   $aRepetitive Structures in Biological Sequences: Algorithms and Applications$93020256
997   $aUNINA