LEADER 01057nam0 22002771i 450 001 UON00405167 005 20231205104714.692 100 $a20120213d1966 |0itac50 ba 101 $arum$aENG 102 $aRO 105 $a|||| 1|||| 200 1 $aDictionar de buzunar$eRoman - Englez$fSerban Andronescu 205 $aeditia a 2.-a 210 $a[Bucuresti]$cEditura Stiintifica$d1966 215 $a223 p.$d16 cm. 606 $aLINGUA ROMENA$xDIZIONARI INGLESI$3UONC074504$2FI 620 $aRO$dBucure?ti$3UONL000071 676 $a459.3$cLINGUA ROMENA - DIZIONARI$v20 700 1$aANDRONESCU$bSerban$3UONV207602$0707841 712 $aEditura ?tiin?ifica ?i Enciclopedic?$3UONV252341$4650 801 $aIT$bSOL$c20240220$gRICA 899 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$2UONSI 912 $aUON00405167 950 $aSIBA - SISTEMA BIBLIOTECARIO DI ATENEO$dSI FONDO ONCIULESCU DIZIONARI 0046 $eSI RO 111 7 0046 996 $aDictionar de buzunar$91344313 997 $aUNIOR LEADER 03135nam 2200397z- 450 001 9910261145303321 005 20210212 035 $a(CKB)4100000002484639 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/62228 035 $a(oapen)doab62228 035 $a(EXLCZ)994100000002484639 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aViral Interactions with the Nucleus 210 $cFrontiers Media SA$d2017 215 $a1 online resource (124 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-247-6 330 $aViruses cause numerous medically important diseases, affecting developing, developed, rich and poor alike. The diseases vary in severity, including chickenpox, smallpox, influenza, shingles, herpes, rabies, polio, Ebola, hanta fever, AIDS and the common cold, amongst others. Regardless of the type of tissue or organ affected, all viruses follow the same basic steps to infect host cells. Once in contact with host cells viruses release their genetic material into the cell followed by genome replication, production of viral proteins, assembly of the virus particle and egress from the infected cell. Viruses disrupt normal host cell processes in order to facilitate their own replication/assembly by re-directing cellular machinery for viral transcription, translation, assembly, release and by inhibiting antiviral responses. Regulated nuclear transport of macromolecules through the nuclear pore complex, the only means of transport across the nuclear membrane, is essential for normal cell function and an effective antiviral response. Many viruses disrupt or exploit the nucleocytoplasmic trafficking pathways in host cells. Cytoplasmic viruses exploit the host cell nucleocytoplasmic trafficking machinery to access nuclear functions and/or disrupt nuclear transport, while several DNA viruses use the trafficking pathways to enable export of their components into the cytoplasm; yet others complete their assembly within the nucleus and use nuclear export pathways to access the cytoplasm. Indeed, the many and varied interactions of viruses and viral proteins with nucleocytoplasmic trafficking components have been invaluable in pathway discovery. Importantly, mounting evidence suggests that these interactions play essential roles in virus replication/assembly and hence may be key to understanding pathophysiology of viral diseases. This Frontiers Research Topic is dedicated to the importance of nucleocytoplasmic trafficking to viral pathogenesis. 606 $aMicrobiology (non-medical)$2bicssc 610 $aDNA Viruses 610 $anuclear pore complex 610 $anuclear transport 610 $aRNA Viruses 610 $aviral nuclear interactions 615 7$aMicrobiology (non-medical) 700 $aErin Joanne Walker$4auth$01326356 702 $aReena Ghildyal$4auth 906 $aBOOK 912 $a9910261145303321 996 $aViral Interactions with the Nucleus$93037369 997 $aUNINA