LEADER 02406nam  2200373z- 450 
001 9910261142903321
005 20210211
035   $a(CKB)4100000002484663
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/52887
035   $a(oapen)doab52887
035   $a(EXLCZ)994100000002484663
100   $a20202102d2016      |y         0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 00$aMatricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies
210   $cFrontiers Media SA$d2016
215   $a1 online resource (129 p.)
225 1 $aFrontiers Research Topics
311 08$a2-88945-024-4 
330   $aThe invasive character of a primary cancer is greatly dependent on numerous interactions between tumor cells and their extracellular surroundings. Matricellular receptors are defined as (cell-surface) receptors that bind extracellular matrix (ECM) structural proteins and soluble factors dynamically acting on ECM homeostasis. Matricellular receptors mediate numerous signalings from the extracellular environment to cell nucleus and drive main biological functions that are cell growth, survival and migration. Numerous data from the last decade evidence that matricellular receptors are biosensors that allow to a tumor cell answering to microenvironmental variations, and in this sense they are important contributors to tumor cell malignancy. Matricellular receptors represent thus valuable targets for the development of original anti-cancer strategies. Original reports, bibliographic reviews or hypotheses are welcome to improve the basic knowledge of matricellular receptor properties, their spatio-temporal regulation, the dynamic formation of complex receptors and the impact of such interactions on the invasive properties of tumor cells. Biological, biophysical and pharmacological, as well as in silico contributions will be appreciated.
606   $aPharmacology$2bicssc
610   $aAnti-cancer target
610   $adisco
615  7$aPharmacology
700   $aHerve Emonard$4auth$01317893
702   $aStephane Dedieu$4auth
702   $aLaurent Duca$4auth
906   $aBOOK
912   $a9910261142903321
996   $aMatricellular Receptors as Potential Targets in Anti-Cancer Therapeutic Strategies$93033061
997   $aUNINA