LEADER 03058nam  2200409z- 450 
001 9910261142303321
005 20231214133241.0
035   $a(CKB)4100000002484669
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/49990
035   $a(EXLCZ)994100000002484669
100   $a20202102d2017      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aImmunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases
210   $cFrontiers Media SA$d2017
215   $a1 electronic resource (108 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-288-3 
330   $aMore than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases.
610   $aDrugs
610   $aMultiple sclerosis
610   $aNK cells
610   $aLeukemia
610   $aAIDS
610   $aAdjuvants
610   $aLymphoma
610   $aAutophagy
610   $aChemokines
610   $aCancer
700   $aAzzam A. Maghazachi$4auth$01306124
906   $aBOOK
912   $a9910261142303321
996   $aImmunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases$93028289
997   $aUNINA