LEADER 02876nam  2200397z- 450 
001 9910261141103321
005 20231214133253.0
035   $a(CKB)4100000002484681
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/43255
035   $a(EXLCZ)994100000002484681
100   $a20202102d2017      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aCircadian Rhythms and Metabolism
210   $cFrontiers Media SA$d2017
215   $a1 electronic resource (188 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-282-4 
330   $aOne of the major breakthroughs of the last decade in the understanding of energy homeostasis is the identification of a reciprocal control between circadian rhythmicity and cellular metabolism. Circadian rhythmicity is a fundamental endogenous process of almost every organism living on Earth. For instance, the alternation of hunger and satiety is not continuous over 24 h, but is instead structured in time along the light/dark cycle. In mammals, the temporal organization of metabolism, physiology and behavior around 24 h is controlled by a network of multiple cellular clocks, synchronized via neuronal and hormonal signals by a master clock located in the suprachiasmatic nuclei of the hypothalamus. This central circadian conductor in the brain is mainly reset by ambient light perceived by the retina, while secondary circadian clocks in other brain areas and peripheral organs can be reset by meal timing. Chronic disruption of circadian rhythms, as seen in human shift-workers (up to 20% of the active population), has been associated with the development of a number of adverse mental and metabolic conditions. Understanding of the functional links between circadian desynchronization and overall health in animal models and humans, however, is still scarce. Interactions between circadian clocks and metabolism can occur at different levels: the molecular clockwork, internal synchronization via neuro-hormonal signals, or external synchronization via photic or feeding cues. This Research Topic comprises a number of reviews as well as research and methods articles that feature recent advancements in the mechanisms linking circadian clocks with energy metabolism, and the pathophysiological implications of these interactions for metabolic health.
610   $aCircadian clock
610   $amitochondria
610   $afeeding
610   $acircadian desynchronization
610   $aexercise
610   $acancer
610   $aclock gene
610   $aAlzheimer
700   $aEtienne Challet$4auth$01287647
702   $aAndries Kalsbeek$4auth
906   $aBOOK
912   $a9910261141103321
996   $aCircadian Rhythms and Metabolism$93020254
997   $aUNINA