LEADER 02951nam 2200433z- 450 001 9910261141103321 005 20210211 035 $a(CKB)4100000002484681 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/43255 035 $a(oapen)doab43255 035 $a(EXLCZ)994100000002484681 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aCircadian Rhythms and Metabolism 210 $cFrontiers Media SA$d2017 215 $a1 online resource (188 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-282-4 330 $aOne of the major breakthroughs of the last decade in the understanding of energy homeostasis is the identification of a reciprocal control between circadian rhythmicity and cellular metabolism. Circadian rhythmicity is a fundamental endogenous process of almost every organism living on Earth. For instance, the alternation of hunger and satiety is not continuous over 24 h, but is instead structured in time along the light/dark cycle. In mammals, the temporal organization of metabolism, physiology and behavior around 24 h is controlled by a network of multiple cellular clocks, synchronized via neuronal and hormonal signals by a master clock located in the suprachiasmatic nuclei of the hypothalamus. This central circadian conductor in the brain is mainly reset by ambient light perceived by the retina, while secondary circadian clocks in other brain areas and peripheral organs can be reset by meal timing. Chronic disruption of circadian rhythms, as seen in human shift-workers (up to 20% of the active population), has been associated with the development of a number of adverse mental and metabolic conditions. Understanding of the functional links between circadian desynchronization and overall health in animal models and humans, however, is still scarce. Interactions between circadian clocks and metabolism can occur at different levels: the molecular clockwork, internal synchronization via neuro-hormonal signals, or external synchronization via photic or feeding cues. This Research Topic comprises a number of reviews as well as research and methods articles that feature recent advancements in the mechanisms linking circadian clocks with energy metabolism, and the pathophysiological implications of these interactions for metabolic health. 606 $aMedicine$2bicssc 610 $aAlzheimer 610 $acancer 610 $aCircadian clock 610 $acircadian desynchronization 610 $aclock gene 610 $aexercise 610 $afeeding 610 $amitochondria 615 7$aMedicine 700 $aEtienne Challet$4auth$01287647 702 $aAndries Kalsbeek$4auth 906 $aBOOK 912 $a9910261141103321 996 $aCircadian Rhythms and Metabolism$93020254 997 $aUNINA