LEADER 02885nam 2200469z- 450 001 9910261140803321 005 20210212 035 $a(CKB)4100000002484684 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/61458 035 $a(oapen)doab61458 035 $a(EXLCZ)994100000002484684 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aUbiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System 210 $cFrontiers Media SA$d2017 215 $a1 online resource (241 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-285-9 330 $aProteolysis by the ubiquitin-proteasome pathway (UPP) in the nervous system has been extensively studied both in the context of normal physiological function as well as abnormal pathological conditions. Although ubiquitin was used as a marker of brain pathology, the normal functions of the UPP were not studied much in the nervous system until the 1990s. The early investigations focused on synaptic plasticity which was followed by studies on the roles of protein degradation in the development of the nervous system. Research on the role of abnormal roles of the UPP follows a parallel trajectory. Since the 2000s, the field has grown to encompass many subareas of research and several model systems. Despite the progress made, many unanswered questions still remain. For example, there are many unknowns about the precise spatial and temporal control of protein degradation in the normal nervous system. With respect to the roles of proteolysis in brain pathology a major challenge is to elucidate the connection between impaired protein degradation and disease progression. In addition, in-depth studies of the roles of ubiquitin-proteasome-mediated proteolysis in neurodegenerative diseases are promising in identifying therapeutic targets. This ebook contains original research papers and insightful reviews that cover several aspects of proteolysis by the UPP and its physiological as well as pathological functions in the nervous system. 517 $aUbiquitin and the Brain 606 $aNeurosciences$2bicssc 610 $aaging 610 $aAlzheimer's disease 610 $adeubiquitinating 610 $aglutamate receptors 610 $aHuntington's disease 610 $amemory 610 $aneurodegenerative 610 $aneuroinflammation 610 $aproteasome 610 $asynaptic plasticity 615 7$aNeurosciences 700 $aAshok N. Hegde$4auth$01292331 702 $aFred W. van Leeuwen$4auth 906 $aBOOK 912 $a9910261140803321 996 $aUbiquitin and the Brain: Roles of Proteolysis in the Normal and Abnormal Nervous System$93022180 997 $aUNINA