LEADER 03195nam 2200481z- 450 001 9910261140303321 005 20210211 035 $a(CKB)4100000002484689 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/42315 035 $a(oapen)doab42315 035 $a(EXLCZ)994100000002484689 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aBK Channels: Integrators of Cellular Signals in Health and Disease 210 $cFrontiers Media SA$d2017 215 $a1 online resource (183 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-291-3 330 $aMaxi calcium-activated potassium channels (BK) are an amazing category of ion channels which are found in cellular plasma membranes as well as in membranes of intracellular organelles. The function of these channels is to repolarize any excited membrane by passing a potassium outward current, in response to depolarization and/or increase in local calcium levels. Thus, voltage and calcium ions are involved in gating the channel under physiological conditions. This dual activation makes them perfect sensors for many cellular events that require integration between intracellular calcium levels and electrical signals. A plethora of physiological and pathophysiological functions, such as membrane hyperpolarization, modulation of synaptic transmission, hormone secretion or mental deficiencies, vaso-regulation, epilepsies, heart diseases, myotonic dystrophies, hypertension etc, in almost all cells and tissues were reported for these channels. BK channels are main targets for important ligands like alcohol and gaseous neurotransmitters, such as NO, CO or H2S, to name a few. In the last years, the molecular entities and mechanisms involved in modulation of BK channels have gained tremendous attention, as the key role of these channels in cellular processes became increasingly recognized. Indeed, accessory proteins such as slob, beta and gamma subunits, all serve to modulate the channel gating characteristics. Moreover, channel subunit expression and function is further tuned by phosphorylation/ dephosphorylation processes, redox mechanisms and the lipid microenvironment of the BK channel protein complex. This e-book contains structural and functional aspects of BK channels, channel modulation by a variety of agents and cellular components, as well as the channel's relevance in health and disease. 517 $aBK Channels 606 $aPhysiology$2bicssc 610 $aBK channel 610 $adisease 610 $aethanol 610 $ahealth 610 $ahydrogensulfide 610 $aischemia 610 $aKCNMA1 610 $amaxi calcium activated potassium channel 610 $anervous system 610 $aSlo 615 7$aPhysiology 700 $aAlex Dopico$4auth$01311561 702 $aThomas M. Weiger$4auth 702 $aAnton Hermann$4auth 906 $aBOOK 912 $a9910261140303321 996 $aBK Channels: Integrators of Cellular Signals in Health and Disease$93030422 997 $aUNINA