LEADER 02125nam 2200433z- 450 001 9910261140103321 005 20231214133255.0 035 $a(CKB)4100000002484691 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/62249 035 $a(EXLCZ)994100000002484691 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aVirus Discovery by Metagenomics: The (Im)possibilities 210 $cFrontiers Media SA$d2017 215 $a1 electronic resource (216 p.) 225 1 $aFrontiers Research Topics 311 $a2-88945-308-1 330 $aSince the late 1800s, the discovery of new viruses was a gradual process. Viruses were described one by one using a suite of techniques such as (electron) microscopy and viral culture. Investigators were usually interested in a disease state within an organism, and expeditions in viral ecology were rare. The advent of metagenomics using high-throughput sequencing has revolutionized not only the rate of virus discovery, but also the nature of the discoveries. For example, the viral ecology and etiology of many human diseases are being characterized, non-pathogenic viral commensals are ubiquitous, and the description of environmental viromes is making progress. This Frontiers in Virology Research Topic showcases how metagenomic and bioinformatic approaches have been combined to discover, classify and characterize novel viruses. 517 $aVirus Discovery by Metagenomics 610 $avirome 610 $abiological dark matter 610 $ametagenome 610 $ametagenomics 610 $abacteriophages 610 $abioinformatics 610 $avirus discovery 610 $aphages 700 $aKatrine L. Whiteson$4auth$01292330 702 $aAlejandro Reyes$4auth 702 $aRichard J. Hall$4auth 702 $aBas E. Dutilh$4auth 906 $aBOOK 912 $a9910261140103321 996 $aVirus Discovery by Metagenomics: The (Im)possibilities$93022179 997 $aUNINA