LEADER 02639nam 2200385z- 450 001 9910261139003321 005 20231214133137.0 035 $a(CKB)4100000002484702 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/50187 035 $a(EXLCZ)994100000002484702 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aInflammation in the CNS: Advancing the Field Using Intravital Imaging 210 $cFrontiers Media SA$d2017 215 $a1 electronic resource (108 p.) 225 1 $aFrontiers Research Topics 311 $a2-88945-364-2 330 $aInflammation of the CNS can have devastating, long-lived, and in some cases fatal consequences for patients. The stimuli that can induce CNS inflammation are diverse, and include infectious agents, autoimmune responses against CNS-expressed antigens, and sterile inflammation following ischemia or traumatic injury. In these conditions, cells of the immune system play central roles in promulgation and resolution of the inflammatory response. However, the immunological mechanisms at work in these diverse responses differ according to the nature of the response. Our understanding of the actions of immune cells in the CNS has been restricted by the difficulty in visualising leukocytes as they undergo recruitment from the cerebral microvasculature and following their entry into the CNS parenchyma. However, advances in in vivo microscopy over the last 10-15 years have overcome many of these difficulties, and studies using these forms of microscopy have revealed a wealth of new information regarding the cellular and molecular mechanisms of CNS inflammation. This Research Topic brings together state of the art reviews examining the use of in vivo imaging in investigating inflammation and leukocyte behaviour in the CNS. Papers in this Research Topic describe how in vivo microscopy has increased our understanding of the actions of immune cells in the inflamed CNS, following various stimuli including autoimmunity, infection and sterile inflammation. 517 $aInflammation in the CNS 610 $aIntravital Imaging 610 $aBrain 610 $aInflammation 610 $aCNS disorders 610 $aLeukocytes 700 $aSaparna Pai$4auth$01331583 702 $aWolfgang Weninger$4auth 702 $aMichael J. Hickey$4auth 906 $aBOOK 912 $a9910261139003321 996 $aInflammation in the CNS: Advancing the Field Using Intravital Imaging$93040456 997 $aUNINA