LEADER 03136nam  2200445z- 450 
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035   $a(CKB)4100000002484711
035   $a(oapen)https://directory.doabooks.org/handle/20.500.12854/55792
035   $a(EXLCZ)994100000002484711
100   $a20202102d2017      |y             0
101 0 $aeng
135   $aurmn|---annan
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aPathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic
210   $cFrontiers Media SA$d2017
215   $a1 electronic resource (220 p.)
225 1 $aFrontiers Research Topics
311   $a2-88945-317-0 
330   $aThe basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of diseases known as movement disorders, including Parkinson's disease, Huntington's disease, dystonia and Gilles de la Tourette syndrome, among others. Additionally, the presence of a number of circuits within the basal ganglia related to non-motor functions has been acknowledged. Currently, the basal ganglia are thought to participate in cognitive, limbic and learning functions. Moreover, disorders related to the basal ganglia are known to involve a number of complex, non-motor symptoms and syndromes (e.g. compulsive and addictive behavior). In the light of this evidence, it is becoming clear that our knowledge about the basal ganglia needs to be revised, and that new pathophysiological models of movement disorders are needed. In this context, the study of the pathophysiology of the basal ganglia and the treatment of their pathology is becoming increasingly interdisciplinary. Nowadays, an appropriate approach to the study of these problems must necessarily involve the use of complex mathematical modeling, computer simulations, basic research (ranging from biomolecular studies to animal experimentation), and clinical research. This research topic aims to bring together the most recent advances related to the pathophysiology of the basal ganglia and movement disorders.
517   $aPathophysiology of the Basal Ganglia and Movement Disorders
610   $aBraak's hypothesis
610   $abasal ganglia
610   $aParkinson's disease
610   $acycling
610   $amovement disorders
610   $acomputational modeling
610   $aHuntington's disease
610   $anon-motor symptoms
610   $anonlinear dynamics
610   $adeep brain stimulation
700   $aOlivier Darbin$4auth$01311262
702   $aDaniela Andres$4auth
702   $aMarcelo Merello$4auth
906   $aBOOK
912   $a9910261138103321
996   $aPathophysiology of the Basal Ganglia and Movement Disorders: Gaining New Insights from Modeling and Experimentation to Influence the Clinic$93030069
997   $aUNINA