LEADER 02355nam 2200433z- 450 001 9910261137703321 005 20231214133127.0 035 $a(CKB)4100000002484715 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/53610 035 $a(EXLCZ)994100000002484715 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMitogen Activated Protein Kinases 210 $cFrontiers Media SA$d2017 215 $a1 electronic resource (163 p.) 225 1 $aFrontiers Research Topics 311 $a2-88945-339-1 330 $aMitogen-activated protein kinase (MAPK) pathways are evolutionarily conserved in all eukaryotes and allow cells to respond to changes in the physical and chemical properties of the environment and to produce an appropriate response by altering many cellular functions. MAPKs are among the most intensively studied signal transduction systems. MAPK research is a very dynamic field in which new perspectives are continuously opening to the scientific community. Importantly, many MAPK inhibitors have been developed during the last years and are currently being tested in preclinical and clinical assays for inflammatory diseases and cancer treatment. In this research topic, we have gathered 14 papers covering recent advances in different aspects of the MAPK research area that have provided valuable insight into the spatiotemporal dynamics, the regulation and functions of MAPK pathways, as well as their therapeutic potential. We hope that this Research Topic helps readers to have a better understanding of the progresses that have been made recently in the field of MAPK signalling. A deeper understanding of the these pathways will facilitate the development of innovative therapeutic approaches. 610 $akinase 610 $acell differentiation 610 $ap38 610 $aMSK 610 $ascaffold 610 $ainflammation 610 $aJNK 610 $acancer 610 $aMAPK 610 $aERK 700 $aJose Lozano$4auth$01317891 702 $aJose M. Lizcano$4auth 702 $aAna Cuenda$4auth 906 $aBOOK 912 $a9910261137703321 996 $aMitogen Activated Protein Kinases$93033059 997 $aUNINA