LEADER 03905nam 2200433z- 450 001 9910261135403321 005 20210211 035 $a(CKB)4100000002484738 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/56391 035 $a(oapen)doab56391 035 $a(EXLCZ)994100000002484738 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aPlastid Proteostasis: Relevance of Transcription; Translation and Post-Translational Modifications 210 $cFrontiers Media SA$d2017 215 $a1 online resource (110 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-343-X 330 $aDue to their bacterial endosymbiotic origin plastids are organelles with both nuclear-encoded and plastid-encoded proteins. Therefore, a highly integrated modulation of gene expression between the nucleus and the plastome is needed in plant cell development. Plastids have retained for the most part a prokaryotic gene expression machinery but, differently from prokaryotes and eukaryotes, they have largely abandoned transcriptional control and switched to predominantly translational control of their gene expression. Some transcriptional regulation is known to occur, but the coordinate expression between the nucleus and the plastome takes place mainly through translational regulation. However, the regulatory mechanisms of plastid gene expression (PGE) are mediated by intricate plastid-nuclear interactions and are still far from being fully understood. Although, for example, translational autoregulation mechanisms in algae have been described for subunits of heteromeric protein complexes and termed control by epistasy of synthesis (CES), only few autoregulatory proteins have been identified in plant plastids. It should be noted of course that PGE in C. reinhardtii is different from that in plants in many aspects. Another example of investigation in this research area is to understand the interactions that occur during RNA binding between nucleus-encoded RNA-binding proteins and the respective RNA sequences, and how this influences the translation initiation process. In addition to this, the plastid retains a whole series of mechanisms for the preservation of its protein balance (proteostasis), including specific proteases, as well as molecular chaperones and enzymes useful in protein folding. After synthesis, plastid proteins must rapidly fold into stable three dimensional structures and often undergo co- and posttranslational modifications to perform their biological mission, avoiding aberrant folding, aggregation and targeting with the help of molecular chaperones and proteases. We believe that this topic is highly interesting for many research areas because the regulation of PGE is not only of wide interest for plant biologists but has also biotechnological implications. Indeed, plastid transformation turns out to be a very promising tool for the production of recombinant proteins in plants, yet some limitations must still be overcome and we believe that this is mainly due to our limited knowledge of the mechanisms in plastids influencing the maintenance of proteostasis. 517 $aPlastid Proteostasis 606 $aBotany & plant sciences$2bicssc 610 $agene expression 610 $anuclear-plastid interactions 610 $aplastome 610 $aprotein balance 610 $aregulation 615 7$aBotany & plant sciences 700 $aMichele Bellucci$4auth$01326353 702 $aFiammetta Alagna$4auth 702 $aAndrea Pompa$4auth 702 $aDario Leister$4auth 906 $aBOOK 912 $a9910261135403321 996 $aPlastid Proteostasis: Relevance of Transcription; Translation and Post-Translational Modifications$93037366 997 $aUNINA