LEADER 03280nam 2200421z- 450 001 9910261133203321 005 20231214133306.0 035 $a(CKB)4100000002484754 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/46252 035 $a(EXLCZ)994100000002484754 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aEmerging Functions of Septins 210 $cFrontiers Media SA$d2017 215 $a1 electronic resource (126 p.) 225 1 $aFrontiers Research Topics 311 $a2-88945-287-5 330 $aTogether with the microfilament, microtubule and intermediate-filament networks, septins constitute an integral part of the eukaryotic cytoskeleton. Historically identified as proteins critical for septum formation in the budding yeast Saccharomyces cerevisiae, septin family GTPases are expressed and participate in the process of cytokinesis in most eukaryotes except higher plants. More than a dozen septin genes in mammals, together with various splice variants displaying tissue-specific expression patterns and flexible hetero-polymeric higher-order assembly achieve an unfathomable complexity superior to the other cytoskeletal components. Even though the initial studies in the septin field was restricted to their evolutionarily conserved role in cell division, strong expression of septins in the non-dividing cells of the brain generated great interest in understanding their role in neuronal morphogenesis and other aspects of cellular function. On one hand, recent developments indicate complex non-canonical roles for septins in diverse processes ranging from neuronal development to immune response and calcium signaling. On the other hand several lines of data including those from knockout models question the universal role for septins in animal cell cytokinesis. Mammalian hematopoietic cells seem to proliferate and efficiently undergo cytokinesis in the absence of pivotal septin proteins in a context-dependent manner. The lack of septin-dependence of hematopoiesis also opens the possibility of safely targeting septin-dependent cytokinesis for solid-tumor therapy. Thus the septin field is perfectly poised with novel roles for septins being discovered and the basic understanding on septin assembly and its canonical functions constantly revisited. The objective of this research topic was to provide an exclusive platform for discussing these rapid advances in the septin field. With a mixture of reviews and research articles encompassing diverse areas of septin research, ranging from the humble yeast model to human cancer, this ebook will be an interesting reading material for both experts as well as new comers to the septin field. 610 $amutation 610 $acytoskeleton 610 $acytokinesis 610 $abudding 610 $aSOCE 610 $aseptin 610 $acancer 610 $aGTPase 610 $ayeast 610 $aCilia 700 $aManoj B. Menon$4auth$01331580 702 $aMatthias Gaestel$4auth 906 $aBOOK 912 $a9910261133203321 996 $aEmerging Functions of Septins$93040453 997 $aUNINA