LEADER 03790nam 22006375 450 001 9910255259803321 005 20240322053915.0 010 $a9783319622323 010 $a3319622323 024 7 $a10.1007/978-3-319-62232-3 035 $a(CKB)4100000000587705 035 $a(DE-He213)978-3-319-62232-3 035 $a(MiAaPQ)EBC5042231 035 $a(Perlego)3496727 035 $a(EXLCZ)994100000000587705 100 $a20170908d2017 u| 0 101 0 $aeng 135 $aurnn#008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAlternative Worlds Imagined, 1500-1700 $eEssays on Radicalism, Utopianism and Reality /$fby James Colin Davis 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Palgrave Macmillan,$d2017. 215 $a1 online resource (VIII, 246 p.) 225 1 $aPalgrave Studies in Utopianism,$x2946-448X 300 $aIncludes index. 311 08$a9783319622316 311 08$aversion imprimée 3319622315 327 $a1. Introduction -- 2. Radicalism in a traditional society: The valuation of radical thought in the English Commonwealth, 1649-1660 -- 3. Afterword: Reassessing radicalism in a traditional society: two questions -- 4. Conquering the Conquest: the limits of non-violence in Gerrard Winstanley's thought' -- 5. Formal Utopia/Informal Millennium: the struggle between form and substance as a context for seventeenth-century utopianism -- 6. Against Formality: one aspect of the English Revolution -- 7. Religion and the struggle for freedom in the English Revolution -- 8. Thomas More's Utopia: sources, legacy and interpretation -- 9. Goodbye to Utopia: Thomas More's Utopian conclusion -- 10. James Harrington's utopian radicalism and the narration of an alternative world -- 11. Conclusion. 330 $aThis book address the relationship between utopian and radical thought, particularly in the early modern period, and puts forward alternatives approaches to imagined 'realities'. Alternative Worlds Imagined, 1500-1700 explores the nature and meaning of radicalism in a traditional society; the necessity of fiction both in rejecting and constructing the status quo; and the circumstances in which radical and utopian fictions appear to become imperative. In particular, it closely examines non-violence in Gerrard Winstanley's thought; millennialism and utopianism as mutual critiques; form and substance in early modern utopianism/radicalism; Thomas More's utopian theatre of interests; and James Harrington and the political necessity of narrative fiction. This detailed analysis underpins observations about the longer term historical significance and meaning of both radicalism and utopianism. 410 0$aPalgrave Studies in Utopianism,$x2946-448X 606 $aIntellectual life$xHistory 606 $aGreat Britain$xHistory 606 $aEurope$xHistory$x1492- 606 $aWorld politics 606 $aIntellectual History 606 $aHistory of Britain and Ireland 606 $aHistory of Early Modern Europe 606 $aHistory of Modern Europe 606 $aPolitical History 615 0$aIntellectual life$xHistory. 615 0$aGreat Britain$xHistory. 615 0$aEurope$xHistory$x1492-. 615 0$aWorld politics. 615 14$aIntellectual History. 615 24$aHistory of Britain and Ireland. 615 24$aHistory of Early Modern Europe. 615 24$aHistory of Modern Europe. 615 24$aPolitical History. 676 $a901 700 $aDavis$b James Colin$4aut$4http://id.loc.gov/vocabulary/relators/aut$0153708 906 $aBOOK 912 $a9910255259803321 996 $aAlternative Worlds Imagined, 1500-1700$92138007 997 $aUNINA LEADER 03999nam 2200445z- 450 001 9910261134603321 005 20210211 035 $a(CKB)4100000002484746 035 $a(oapen)https://directory.doabooks.org/handle/20.500.12854/44997 035 $a(oapen)doab44997 035 $a(EXLCZ)994100000002484746 100 $a20202102d2017 |y 0 101 0 $aeng 135 $aurmn|---annan 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 00$aDiacylglycerol Kinase Signalling 210 $cFrontiers Media SA$d2017 215 $a1 online resource (96 p.) 225 1 $aFrontiers Research Topics 311 08$a2-88945-335-9 330 $aDiacylglycerol kinases (DGKs) phosphorylate diacylglycerol (DG), catalyzing its conversion into phosphatidic acid (PA). This reaction attenuates membrane DG levels, limiting the localization/activation of signaling proteins that bind this lipid. Initially recognized as modulators of classical and novel PKC family members, the function of the DGK has further expanded with the identification of novel DG effectors including Ras Guanyl nucleotide-releasing proteins (RasGRP) and chimaerin Rac GTPases. The product of the DGK reaction, PA, is also a signaling lipid that mediates activation of multiple proteins including the mammalian target of rapamycin (mTOR). The DGK pathway thus modulates two lipids with important signaling properties that are also key intermediates in lipid metabolism and membrane trafficking. The DGK family in eukaryotes comprises 10 different members grouped into five different subfamilies characterized by the presence of particular regulatory motifs. These regions allow the different DGK isoforms to establish specific complexes and/or to be recruited to specific subcellular compartments. The subtle regulation of DG and PA catalyzed byspecific DGKs is sensed by a restricted set of molecules, providing the means for spatio-temporal regulation of signals in highly specialized cell systems. In the recent years, multiple studies have unveiled the functions of specific isoforms, their mechanisms of regulation and their participation in different pathways leading to and from DG and PA. Animal models have greatly helped to understand the specialized contribution of DGK mediated signals, particularly in the immune and central nervous systems. Mice deficient for individual DGK isoforms show defects in T and B cell functions, dendritic spine maintenance, osteoclast and mechanical-induced skeletal muscle formation. Studies in flies and worms link DGK mediated DAG metabolism with mTOR- mediated regulation of lifespan and stress responses. In plants DGK mediated PA formation contributes to plant responses to environmental signals. Aberrant DGK function has been recently associated with pathological states, an expected consequence of the essential role of these enzymes in the regulation of multiple tissue and systemic functions. DGK mutations/deletions have been related to human diseases including diabetes, atypical hemolytic-uremic syndrome, Parkinson disease and bipolar disorders. On the contrary DGK upregulation emerges as a non-oncogenic addition of certain tumors and represents one of the main mechanism by which cancer evades the immune attack. As a result, the DGK field emerges an exciting new area of research with important therapeutic potential. 606 $aBiology, life sciences$2bicssc 610 $acytotoxic T cells 610 $aimmune system 610 $aimmunotherapy of cancer 610 $alipid signaling 610 $asynaptic plasticity (LTP/LTD) 610 $asynaptic transmission 610 $aT cell receptor 610 $atolerance 615 7$aBiology, life sciences 700 $aAndrea Graziani$4auth$01320420 702 $aFumio Sakane$4auth 702 $aIsabel Merida$4auth 906 $aBOOK 912 $a9910261134603321 996 $aDiacylglycerol Kinase Signalling$93034285 997 $aUNINA