LEADER 03469nam 22005055 450 001 9910254650103321 005 20200704100653.0 010 $a3-319-55825-0 024 7 $a10.1007/978-3-319-55825-7 035 $a(CKB)3710000001418443 035 $a(MiAaPQ)EBC4891390 035 $a(DE-He213)978-3-319-55825-7 035 $a(PPN)202992039 035 $a(EXLCZ)993710000001418443 100 $a20170629d2017 u| 0 101 0 $aeng 135 $aurcnu|||||||| 181 $2rdacontent 182 $2rdamedia 183 $2rdacarrier 200 10$aPatient-Derived Xenograft Models of Human Cancer /$fedited by Yuzhuo Wang, Dong Lin, Peter W. Gout 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2017. 215 $a1 online resource (204 pages) 225 1 $aMolecular and Translational Medicine,$x2197-7852 311 $a3-319-55824-2 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroduction -- History and Evolution of PDX Cancer Models -- Establishment and Characterization of PDX Models -- Methods of Generating PDX Models -- Fidelity and Stability of PDX Models -- Applications of PDX Models -- Studies of Cancer Heterogeneity -- PDX and Cancer Stem Cells -- Modeling Cancer Metastasis -- Modeling Drug Resistance -- PDX and Biomarker Development -- PDX and Preclinical Drug Screening -- Co-clinical Trials and Personalized Cancer Therapy/Precision Medicine -- Epilogue -- Future Perspective. 330 $aThis book provides a comprehensive, state-of-the-art review of PDX cancer models. In separately produced chapters, the history and evolution of PDX models is reviewed, methods of PDX model development are compared in detail, characteristics of available established models are presented, current applications are summarized and new perspectives about use of PDX models are proposed. Each chapter is written by a world-renowned expert who is conducting cutting-edge research in the field. Each of the subsections provide a comprehensive review of existing literature addressing the particular topic followed by a conclusive paragraph detailing future directions. Extensive illustrations make this an interactive text. Patient-Derived Xenograft Models of Human Cancer will serve as a highly useful resource for researchers and clinicians dealing with, or interested in, this important topic. It will provide a concise yet comprehensive summary of the current status of the field that will help guide preclinical and clinical applications as well as stimulate investigative efforts. This book will propagate innovative concepts and prompt the development of ground-breaking technological solutions in this field. 410 0$aMolecular and Translational Medicine,$x2197-7852 606 $aOncology 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 615 0$aOncology. 615 14$aOncology. 676 $a616.9940072 702 $aWang$b Yuzhuo$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aLin$b Dong$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGout$b Peter W$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254650103321 996 $aPatient-Derived Xenograft Models of Human Cancer$91757962 997 $aUNINA