LEADER 03941nam 22006015 450 001 9910254582603321 005 20200629144443.0 010 $a3-319-55539-1 024 7 $a10.1007/978-3-319-55539-3 035 $a(CKB)3710000001364474 035 $a(DE-He213)978-3-319-55539-3 035 $a(MiAaPQ)EBC4858665 035 $a(PPN)201471876 035 $a(EXLCZ)993710000001364474 100 $a20170515d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMolecular Basis for Mitochondrial Signaling$b[electronic resource] /$fedited by Tatiana K. Rostovtseva 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (XIV, 386 p. 61 illus., 54 illus. in color.) 225 1 $aBiological and Medical Physics, Biomedical Engineering,$x1618-7210 311 $a3-319-55537-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aFrom the Contents: Mitochondrial Calcium Signaling -- Systems approaches to mitochondrial calcium signaling -- The mitochondrial Calcium Uniporter: Molecular Composition And Physiological Role -- Molecular Mechanisms of Mitochondrial Ca2+ Uptake -- Ca2+ uniporter and male fertility. 330 $aThis book covers recent advances in the study of structure, function, and regulation of metabolite, protein and ion translocating channels, and transporters in mitochondria. A wide array of cutting-edge methods are covered, ranging from electrophysiology and cell biology to bioinformatics, as well as structural, systems, and computational biology. At last, the molecular identity of two important channels in the mitochondrial inner membrane, the mitochondrial calcium uniporter and the mitochondrial permeability transition pore have been established. After years of work on the physiology and structure of VDAC channels in the mitochondrial outer membrane, there have been multiple discoveries on VDAC permeation and regulation by cytosolic proteins. Recent breakthroughs in structural studies of the mitochondrial cholesterol translocator reveal a set of novel unexpected features and provide essential clues for defining therapeutic strategies. Molecular Basis for Mitochondrial Signaling covers these and many more recent studies of mitochondria function, their communication with other organelles, and their critical roles in development, aging, and in a plethora of stressful or degenerative events. Authored by leading researchers in the field, this volume will be an indispensable reference resource for graduate students and academics working in related areas of biophysics and cell biology as well as for professionals within industry. 410 0$aBiological and Medical Physics, Biomedical Engineering,$x1618-7210 606 $aBiophysics 606 $aBiological physics 606 $aCell cycle 606 $aApoptosis 606 $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008 606 $aCell Cycle Analysis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16030 606 $aApoptosis$3https://scigraph.springernature.com/ontologies/product-market-codes/L16060 615 0$aBiophysics. 615 0$aBiological physics. 615 0$aCell cycle. 615 0$aApoptosis. 615 14$aBiological and Medical Physics, Biophysics. 615 24$aCell Cycle Analysis. 615 24$aApoptosis. 676 $a571.657 702 $aRostovtseva$b Tatiana K$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254582603321 996 $aMolecular Basis for Mitochondrial Signaling$91832424 997 $aUNINA