LEADER 04859nam 22007935 450 001 9910254578603321 005 20200706060925.0 010 $a3-319-60501-1 024 7 $a10.1007/978-3-319-60501-2 035 $a(CKB)4340000000061867 035 $a(DE-He213)978-3-319-60501-2 035 $a(MiAaPQ)EBC4917595 035 $a(PPN)203669673 035 $a(EXLCZ)994340000000061867 100 $a20170718d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDual-Mode Electro-photonic Silicon Biosensors /$fby José Juan Colás 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (XV, 149 p. 105 illus., 89 illus. in color.) 225 1 $aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 311 $a3-319-60500-3 320 $aIncludes bibliographical references at the end of each chapters. 327 $aIntroduction -- Fundamentals of Label-Free Biosensing -- Fabrication and Experimental Techniques -- The Electro-photonic Silicon Biosensor -- Study and Application of Electrografted Layers of Diazonium Ions -- Tailoring Light-matter Interaction for Quanti?cation of Biological and Molecular Layers -- Conclusions and Outlook. 330 $aThis highly interdisciplinary thesis reports ontwo innovative photonic biosensors that combine multiple simultaneous measurements to provide unique insights into the activity and structure of surface immobilized biological molecules. In addition, it presents a new silicon photonic biosensor that exploits two cascaded resonant sensors to provide two independent measurements of a biological layer immobilized on the surface. By combining these two measurements, it is possible to unambiguously quantify the density and thickness of the molecular layer; here, the approach?s ability to study molecular conformation and conformational changes in real timeis demonstrated. The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed by simultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics. 410 0$aSpringer Theses, Recognizing Outstanding Ph.D. Research,$x2190-5053 606 $aBiophysics 606 $aBiological physics 606 $aOptical materials 606 $aElectronic materials 606 $aElectrochemistry 606 $aPhysical measurements 606 $aMeasurement    606 $aSurfaces (Physics) 606 $aInterfaces (Physical sciences) 606 $aThin films 606 $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008 606 $aOptical and Electronic Materials$3https://scigraph.springernature.com/ontologies/product-market-codes/Z12000 606 $aElectrochemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C21010 606 $aMeasurement Science and Instrumentation$3https://scigraph.springernature.com/ontologies/product-market-codes/P31040 606 $aSurface and Interface Science, Thin Films$3https://scigraph.springernature.com/ontologies/product-market-codes/P25160 615 0$aBiophysics. 615 0$aBiological physics. 615 0$aOptical materials. 615 0$aElectronic materials. 615 0$aElectrochemistry. 615 0$aPhysical measurements. 615 0$aMeasurement   . 615 0$aSurfaces (Physics). 615 0$aInterfaces (Physical sciences). 615 0$aThin films. 615 14$aBiological and Medical Physics, Biophysics. 615 24$aOptical and Electronic Materials. 615 24$aElectrochemistry. 615 24$aMeasurement Science and Instrumentation. 615 24$aSurface and Interface Science, Thin Films. 676 $a610.28 700 $aJuan Colás$b José$4aut$4http://id.loc.gov/vocabulary/relators/aut$0861745 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254578603321 996 $aDual-Mode Electro-photonic Silicon Biosensors$91923085 997 $aUNINA