LEADER 05014nam 22005655 450 001 9910254545503321 005 20200701012004.0 010 $a3-319-28305-7 024 7 $a10.1007/978-3-319-28305-0 035 $a(CKB)3710000000721968 035 $a(DE-He213)978-3-319-28305-0 035 $a(MiAaPQ)EBC4540594 035 $z(PPN)258857692 035 $a(PPN)194376109 035 $a(EXLCZ)993710000000721968 100 $a20160606d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aRadiobiology of Glioblastoma $eRecent Advances and Related Pathobiology /$fedited by Luigi Pirtoli, Giovanni Luca Gravina, Antonio Giordano 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Humana,$d2016. 215 $a1 online resource (XX, 305 p. 49 illus., 39 illus. in color.) 225 1 $aCurrent Clinical Pathology,$x2197-781X 311 $a3-319-28303-0 320 $aIncludes bibliographical references at the end of each chapters. 327 $aIntroduction and Background -- The ?Radio-resistance? of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options -- Radiobiological Hints from Clinical Studies -- Chemo-radiotherapy: Radiation Total Dose and Fractionation -- Clinical Evidence and Radiobiological Background of Particle Radiation Therapy -- Mathematical Modeling of Radiobiological Parameters from Clinical Studies -- Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series -- Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond -- Basic Knowledge of Glioblastoma Radiobiology -- Molecular Radiobiology and Mathematical Modeling -- Genetic and Epigenetic Determinants in Tumor Initiation and Progression -- Tumor Microenvironment -- Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy -- mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models -- Glioma Stem-like Cells and Radiation Resistance -- Hypoxia and Radiation Resistance -- Invasiveness and Radiation Failures -- Nanoparticle Technology for Research Radiobiology -- The Molecular Classification of Glioblastoma as a Translational Instrument -- Translational Perspectives for Gene Therapy -- Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods -- From Molecular to Clinical Radiation Biology -- Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results -- Conclusive Remarks and Perspectives for Future Research. 330 $aThis text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators. . 410 0$aCurrent Clinical Pathology,$x2197-781X 606 $aPathology 606 $aOncology 606 $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X 606 $aOncology$3https://scigraph.springernature.com/ontologies/product-market-codes/H33160 615 0$aPathology. 615 0$aOncology. 615 14$aPathology. 615 24$aOncology. 676 $a616.99481 702 $aPirtoli$b Luigi$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGravina$b Giovanni Luca$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aGiordano$b Antonio$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254545503321 996 $aRadiobiology of Glioblastoma$92514607 997 $aUNINA