LEADER 04235nam 22005895 450 001 9910254543003321 005 20250609111204.0 010 $a3-319-43151-X 024 7 $a10.1007/978-3-319-43151-2 035 $a(CKB)3710000000869874 035 $a(DE-He213)978-3-319-43151-2 035 $a(MiAaPQ)EBC4694503 035 $a(PPN)195511719 035 $a(MiAaPQ)EBC6237961 035 $a(EXLCZ)993710000000869874 100 $a20160921d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aDisordered Vertebral and Rib Morphology in Pudgy Mice $eStructural Relationships to Human Congenital Scoliosis /$fby Frederic Shapiro 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (IX, 123 p. 20 illus., 15 illus. in color.) 225 1 $aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v221 311 08$a3-319-43149-8 320 $aIncludes bibliographical references. 327 $aI. INTRODUCTION -- II. MATERIALS AND METHODS -- 1. Source, distribution, and ages of pudgy and non-affected mice. - 2. Whole mount preparations -- 3. Radiographic studies -- 4. Histologic studies -- 5. Computerized three-dimensional reconstructions -- 6. Previous studies on chick vertebral development and human congenital scoliosis -- III. RESULTS -- 1. Gross appearance -- 2. Whole mount appearances -- 3. Radiographic studies -- 4. Histology studies: vertebrae, ribs, intervertebral discs and ganglia -- 5. Computerized three-dimensional reconstructions -- 6. Chick embryo vertebral development -- 7. Radiology and histopathology of human congenital scoliosis spine -- IV. DISCUSSION -- ion -- 3. The pudgy mouse -- 4. Genetic influences on axial development; mutations identified in mouse models with vertebral deformation -- 5. Congenital scoliosis (human); its similarity with pudgy mouse vertebral abnormalities -- 6. Pathogenesis of pudgy and human congenital scoliosis based on histopathologic studies.-V. CONCLUSIONS -- 1. Implications of pudgy vertebral abnormalities for biologic research -- 2. Implications of pudgy vertebral abnormalities for clinical patient treatment. . 330 $aThis book presents results obtained from the whole mount preparations, radiological, and histological studies of 60 pu/pu and pu/+ mice from late embryo until 3 months of age. Most mice were in the embryo to 6 week age group where vertebral developmental changes are most marked. Although vertebral abnormalities have been identified as due to mutations in the delta-like 3 (Dll3) gene, it is evident that each mouse has differing structural abnormalities. The disorder is analogous to human congenital scoliosis, a common variant of which is spondylocostal dysplasia. The histological studies presented in this book include plastic embedded sections which allow for high level resolution not only of vertebrae, intervertebral discs, and ribs but also of associated spinal cord, nerve roots and ganglia. In addition an overview of embryo and neonatal development in mouse, chick and human vertebrae is provided to better assess how and where deviant pathoanatomy occurs. The book discusses the possible variables involved in creating final deformity beyond the gene abnormality itself. 410 0$aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v221 606 $aMedical genetics 606 $aAnatomy, Comparative 606 $aBiology$xTechnique 606 $aMedical Genetics 606 $aAnimal Anatomy 606 $aExperimental Organisms 615 0$aMedical genetics. 615 0$aAnatomy, Comparative. 615 0$aBiology$xTechnique. 615 14$aMedical Genetics. 615 24$aAnimal Anatomy. 615 24$aExperimental Organisms. 676 $a617.375 700 $aShapiro$b Frederic$4aut$4http://id.loc.gov/vocabulary/relators/aut$0784158 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254543003321 996 $aDisordered Vertebral and Rib Morphology in Pudgy Mice$92523155 997 $aUNINA