LEADER 03209nam  22004935  450 
001 9910254528503321
005 20200701012943.0
010   $a3-319-40697-3
024 7 $a10.1007/978-3-319-40697-8
035   $a(CKB)3710000000852100
035   $a(EBL)4676977
035   $a(DE-He213)978-3-319-40697-8
035   $a(MiAaPQ)EBC4676977
035   $a(PPN)195513517
035   $a(EXLCZ)993710000000852100
100   $a20160909d2016      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aDrugs During Pregnancy $eMethodological Aspects /$fby Bengt Källén
205   $a1st ed. 2016.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016.
215   $a1 online resource (120 p.)
300   $aDescription based upon print version of record.
311   $a3-319-40696-5 
320   $aIncludes bibliographical references at the end of each chapters.
327   $aIntroduction -- The alert clinician -- Animal experiments and adverse drug reaction reports -- Some epidemiological principles -- Pregnancy outcomes with the exception of congenital malformations -- Congenital malformations -- Identification of maternal use of drugs -- The problem of confounding -- Statistics -- Lumping or splitting? Paternal use of drugs -- Timing of drug use and effects on the embryo or fetus -- Repeated studies and meta-analysis -- Pharmacovigilance -- Information on the risk with drug use during pregnancy -- Concluding remarks.
330   $aThis book addresses methodological aspects of epidemiological studies on maternal drug use in pregnancy. Discussing the existing sources of error and how they can produce incorrect conclusions, it examines various epidemiological techniques and assesses their strengths and weaknesses. These refer both to the identification of outcomes (with special emphasis on congenital malformations) and to the types of exposure (drug use). Further, the book discusses the problem of confounding and how to handle it, and provides a simple introduction to statistics. Special situations, e.g. different types of parental exposure, are examined. Lastly, the book discusses pharmacovigilance and the information problem, concluding with a short list of aspects to consider when one wants to evaluate a published paper in the field. Though the book is primarily intended for pharmacologists, gynecologists and obstetricians, it will benefit all doctors working in perinatal care.
606   $aObstetrics
606   $aPharmacotherapy
606   $aObstetrics/Perinatology/Midwifery$3https://scigraph.springernature.com/ontologies/product-market-codes/H26014
606   $aPharmacotherapy$3https://scigraph.springernature.com/ontologies/product-market-codes/H69000
615  0$aObstetrics.
615  0$aPharmacotherapy.
615 14$aObstetrics/Perinatology/Midwifery.
615 24$aPharmacotherapy.
676   $a610
700   $aKällén$b Bengt$4aut$4http://id.loc.gov/vocabulary/relators/aut$0755849
906   $aBOOK
912   $a9910254528503321
996   $aDrugs during pregnancy$92027817
997   $aUNINA