LEADER 01145nam0-2200349---450- 001 990008509060403321 005 20080220170117.0 035 $a000850906 035 $aFED01000850906 035 $a(Aleph)000850906FED01 035 $a000850906 100 $a20070510d1999----km-y0itay50------ba 101 0 $agrc$afre 102 $aFR 105 $aab--a---001gy 200 1 $aAlcée$eFragments$ftexte établi, traduit et annoté par Gauthier Liberman 210 $aParis$cLes Belles Lettres$d1999 215 $a2 v.$cill. a col. o in b. e n.$d20 cm 225 1 $aCollection des Universités de France$iSérie grecque$v392$xISSN 0184-7155 307 $a1.: CXXVII, 95 p., [2] p. di tav. 307 $a2.: 96-279 p., [1] c. di tav. ripieg. 676 $a884.01$v12 rid.$zita 700 0$aAlcaeus$0169418 702 1$aLiberman,$bGauthier 801 0$aIT$bUNINA$c2007$gRICA$2UNIMARC 901 $aBK 912 $a990008509060403321 952 $aP2B-600-B.L.-ALCAEUS1-200A(1)-2002$bBibl. 55463$fFLFBC 952 $aP2B-600-B.L.-ALCAEUS1-200A(2)-2002$bBibl. 55463$fFLFBC 959 $aFLFBC 996 $aAlcée$9732356 997 $aUNINA LEADER 06445nam 22006735 450 001 9910254522103321 005 20200701214836.0 010 $a3-319-19434-8 024 7 $a10.1007/978-3-319-19434-9 035 $a(CKB)3710000000526902 035 $a(EBL)4182805 035 $a(SSID)ssj0001597156 035 $a(PQKBManifestationID)16298444 035 $a(PQKBTitleCode)TC0001597156 035 $a(PQKBWorkID)14885836 035 $a(PQKB)11382865 035 $a(DE-He213)978-3-319-19434-9 035 $a(MiAaPQ)EBC4182805 035 $a(PPN)190885564 035 $a(EXLCZ)993710000000526902 100 $a20151201d2016 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aAnimal Models of Ophthalmic Diseases /$fedited by Chi-Chao Chan 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (165 p.) 225 1 $aEssentials in Ophthalmology,$x1612-3212 300 $aDescription based upon print version of record. 311 $a3-319-19433-X 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aForeword; Preface; Contents; Contributors; Chapter-1; Animal Models of Herpes Keratitis; 1.1 Introduction to Herpes Keratitis ; 1.2 HSV-1 Latency ; 1.3 HSV-1 Keratitis ; 1.3.1 HSV-1 Epithelial Keratitis; 1.3.2 Herpes Stromal Keratitis; 1.3.2.1 Neurotrophic Damage as a Major Component of HSK in Mice; 1.4 Allografts on Corneas with HSK ; References; Commentary; References; Chapter-2; Animal Models of Cataracts; 2.1 Introduction; 2.2 Models of Congenital Cataract; 2.2.1 Crystallins; 2.2.2 Connexins; 2.2.3 Cytoskeletal and Membrane Proteins; 2.3 Models of Age-Related Cataracts 327 $a2.3.1 Diabetic Cataract2.3.2 UV-Induced Cataracts; 2.3.3 Steroid-Induced Cataracts; 2.3.4 Oxygen and Nuclear Cataracts; 2.4 Secondary Cataract; 2.5 Conclusion; References; Commentary; Chapter-3; Animal Models of Glaucoma; 3.1 Introduction; 3.2 Rodent Glaucoma Models; 3.3 Episcleral Vein Injection/Ablation; 3.4 Translimbal Laser Photocoagulation; 3.5 Microbead Injection; 3.6 Other Models of Induced Ocular Hypertension; 3.7 Genetic Mouse and Rat Models; 3.8 Primary Open-Angle Glaucoma Models; 3.9 Primary Angle-Closure Glaucoma Models; 3.10 Pigmentary Dispersion and Exfoliation Glaucoma Models 327 $a3.11 Congenital and Developmental Glaucoma Models3.12 Future Possible Models; 3.13 Conclusions; References; Commentary; Chapter-4; Animal Models of Age-Related Macular Degeneration: Subretinal Inflammation; 4.1 Introduction; 4.2 Inflammation and Age-Related Macular Degeneration; 4.3 Subretinal Inflammation in AMD Animal Models ; 4.3.1 AMD-Associated Risk Factors and Inflammation; 4.3.1.1 Genetic Risk Factors; 4.3.1.2 AMD-Associated Environmental Risk Factors and Inflammation; 4.3.2.1 Suppression of Tonic Anti-Inflammatory Signals; 4.3.2.2 Defective Immunosuppressive Environment 327 $a4.3.2.3 Autoimmune Reaction4.3.3 "Secondary inflammation" AMD Models; 4.4 Conclusion; References; Commentary; Commentary; Chapter-5; Animal Models of Diabetic Retinopathy; 5.1 Introduction and Clinical Context; 5.2 The Need for Animal Models to Understand the Pathophysiology of DR; 5.3 Rodent Models of DR; 5.3.1 Chemically Induced Diabetes in Mice and Rats; 5.3.2 Spontaneous Diabetic Rodents as Models of DR; 5.3.3 Diet-Induced DR in Rodents; 5.4 Dog Models of DR; 5.5 Other Large Animals of DR; 5.6 Non-mammalian Models of DR; 5.7 Models of PDR; 5.7.1 VEGF Overexpression 327 $a5.7.2 Oxygen-Induced Retinopathy5.8 Techniques to Detect Retinal Lesion in Animal Models of Diabetes; 5.8.1 Fundus Colour Imaging; 5.8.2 Confocal Scanning Laser Ophthalmoscope (cSLO); 5.8.3 Optical Coherence Tomography (OCT); 5.8.4 Electroretinogarphy (ERG); 5.9 Conclusion; References; Commentary; Chapter-6; Animal Models of autoimmune uveitis; 6.1 Introduction; 6.2 Why Do We Need Animal Models to Study Human Uveitis?; 6.3 Animal Models of Uveitis Exhibit Clinical Heterogeneity, Similar to Human Uveitis; 6.4 Induced Animal Models of Uveitis; 6.4.1 Experimental Autoimmune Uveitis (EAU) 327 $a6.4.2 Different Uveitogenic Antigens Induce Different Variants of Uveitis 330 $aThis book describes experimental animal models that mimic common human ocular diseases: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves? disease, and intraocular tumors.  In conjunction, these models reflect the diversity and utility of tools used to study human disease.  World expert clinicians discuss each model based on their clinical experience, and the text is supported by numerous photos and diagrams.  Development of suitable experimental models is critical in identifying risk factors for disease, elucidating fundamental molecular mechanisms in disease progression, and providing guidance as to whether or not a particular treatment is safe and effective for humans. Like other forms of medical research, ophthalmology and vision research focuses on the investigation of disease pathogenesis and the discovery of novel therapies through in vitro and in vivo methodology.  The in vivo experiments employ animal models including vertebrates (zebrafish, rodents, rabbits, and primates) and invertebrates (fruit flies and nematodes) for drug screening. In describing the most pertinent animal models of ophthalmic diseases, this book will be of interest to ophthalmologists, vision researchers, fellows, residents, and medical students. 410 0$aEssentials in Ophthalmology,$x1612-3212 606 $aOphthalmology 606 $aAnimal models in research 606 $aOphthalmology$3https://scigraph.springernature.com/ontologies/product-market-codes/H44004 606 $aAnimal Models$3https://scigraph.springernature.com/ontologies/product-market-codes/L25050 615 0$aOphthalmology. 615 0$aAnimal models in research. 615 14$aOphthalmology. 615 24$aAnimal Models. 676 $a617.7 702 $aChan$b Chi-Chao$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254522103321 996 $aAnimal Models of Ophthalmic Diseases$92528961 997 $aUNINA