LEADER 04131nam 22005535 450 001 9910254520303321 005 20200706124615.0 010 $a3-319-30079-2 024 7 $a10.1007/978-3-319-30079-5 035 $a(CKB)3710000000831500 035 $a(DE-He213)978-3-319-30079-5 035 $a(MiAaPQ)EBC4648192 035 $a(PPN)19480450X 035 $a(EXLCZ)993710000000831500 100 $a20160817d2016 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAutophagy Networks in Inflammation$b[electronic resource] /$fedited by Maria Chiara Maiuri, Daniela De Stefano 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (XV, 403 p. 20 illus., 16 illus. in color.) 225 1 $aProgress in Inflammation Research,$x0379-0363 311 $a3-319-30077-6 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aAutophagy in direct pathogen elimination (Xenophagy) -- Autophagy and pattern recognition receptors -- Autophagy and inflammasomes -- Autophagy and Antigen presentation -- Autophagy and regulation of T and B cell function -- Autophagy in chronic inflammation -- The complex crosstalk between autophagy and ROS -- Lipophagy -- Autophagy, phagocytosis and entosis: who eats whom?- Which is the cell fate of inflammatory cells ? Autophagic cell death, pyroptosis, netosis, apoptosis, necrosis -- Host defence (virus/bacteria) -- Neurological diseases -- Pulmonary diseases (emphysema, COPD, etc.) -- Inflammatory bowel disease -- Target autophagy as a novel therapeutic strategy in autoimmune diseases -- Liver and pancreatic diseases -- Obesity -- Aging -- Overview on clinical trials. 330 $aAutophagy principally serves an adaptive function to protect organisms against diverse human pathologies, including cancer and neurodegeneration. Recent developments using in vitro, ex vivo and in vivo models show the involvement of the autophagy pathway in immunity and inflammation. Moreover, direct interactions between autophagy proteins and immune signalling molecules have also been demonstrated. Defects in autophagy - similar to cancer, neurodegenerative diseases and aging - through autophagy gene mutation and/or microbial antagonism, may underlie the pathogenesis of many infectious diseases and inflammatory syndromes. In spite of the increasing awareness of the importance of autophagy in these pathophysiological conditions, this process remains underestimated and is often overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these diseases are still poorly understood. This book reviews the recent advances regarding the functions of the autophagy pathway and autophagy proteins in immunity and inflammation, focusing on their role in self-nonself distinction, their implications in innate and adaptive immune responses and their dysregulation in the pathology of certain inflammatory and autoimmune diseases. 410 0$aProgress in Inflammation Research,$x0379-0363 606 $aImmunology 606 $aCell biology 606 $aInfectious diseases 606 $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000 606 $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008 606 $aInfectious Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33096 615 0$aImmunology. 615 0$aCell biology. 615 0$aInfectious diseases. 615 14$aImmunology. 615 24$aCell Biology. 615 24$aInfectious Diseases. 676 $a616.079 702 $aMaiuri$b Maria Chiara$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aDe Stefano$b Daniela$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910254520303321 996 $aAutophagy Networks in Inflammation$92511961 997 $aUNINA