LEADER 05053nam 22005295 450 001 9910254515603321 005 20230310155038.0 010 $a3-319-23594-X 024 7 $a10.1007/978-3-319-23594-3 035 $a(CKB)3710000000501080 035 $a(EBL)4089853 035 $a(SSID)ssj0001585476 035 $a(PQKBManifestationID)16264038 035 $a(PQKBTitleCode)TC0001585476 035 $a(PQKBWorkID)14865147 035 $a(PQKB)10763254 035 $a(DE-He213)978-3-319-23594-3 035 $a(MiAaPQ)EBC4089853 035 $a(PPN)190520914 035 $a(EXLCZ)993710000000501080 100 $a20151102d2016 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 00$aPulmonary Hypertension $eBasic Science to Clinical Medicine /$fedited by Bradley A. Maron, Roham T. Zamanian, Aaron B. Waxman 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (371 p.) 300 $aDescription based upon print version of record. 311 08$a3-319-23593-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aHistorical Perspective on the Classification and Nomenclature of Pulmonary Hypertension -- The Defining Characteristics of Pulmonary Arterial Hypertension -- Pulmonary Hypertension in Patients Without Pulmonary Arterial Hypertension -- Epidemiology of Pulmonary Hypertension: From Quaternary Referral Centre to the Community -- The Effects of Chronic Hypoxia on Inflammation and Pulmonary Vascular Function -- Genetics of Pulmonary Vascular Disease -- Novel Mechanisms of Disease: Network Biology and MicroRNA Signaling in Pulmonary Hypertension -- Pulmonary Hypertension as a Metabolic Disease -- Renin-Angiotensin-Aldosterone and other Neurohumoral Factors in the Pathogenesis of Pulmonary Hypertension -- Animal Models of Pulmonary Hypertension -- The Cardiopulmonary Hemodynamic Evaluation of Pulmonary Hypertension -- Advanced Imaging in Pulmonary Hypertension -- Assessing Disease State in the Pulmonary Vasculature in Clinical Practice and Research -- Biomarkers and other Methods for Assessing Patient Progress -- Pulmonary Circulatory - Right Ventricular Uncoupling: New Insights into Pulmonary Hypertension Pathophysiology -- Contemporary Pharmacotherapies Involving Nitric Oxide, Prostacyclin, and Endothelin Receptor Signaling Pathways -- Determining the Optimal Approach to Initiating Oral, Inhaled, and Intravenous Therapies in Clinical Practice: Sequential Goal-Directed Therapy is Best -- Counterpoint: Determining the optimal approach to initiating oral, inhaled, and intravenous therapies in clinical practice: Maximal upfront therapy is best -- Surgery, Devices, Transplantation and Other Interventional Options for the Treatment of Advanced Pulmonary Hypertension -- Patient Registries in Pulmonary Arterial Hypertension:  the Role of Survival Equations and Risk Calculators -- Support Care for the Pulmonary Hypertension Patient -- Special Considerations for the Pulmonary Hypertension Patient -- The Future of Pulmonary Hypertension. 330 $aThis definitive textbook details the rapid advances in epidemiology, pathobiology and therapeutics in the field of pulmonary hypertension. Despite recent progress, under-awareness persists within the practicing pulmonary, cardiovascular, and general internal medicine communities. This is due, in part, to the complex array of molecular mechanisms implicated in the pathobiology of PH, as well as cutting-edge discoveries from translational scientific works that provide a new framework by which to understand pulmonary vascular-right ventricular coupling. This book bridges this knowledge gap through the synthesis of a contemporary text that emphasizes basic science, translational and clinical principles, and treatment strategies for understanding pulmonary hypertension. Pulmonary Hypertension: Basic Science to Clinical Medicine is the essential reference for any physician or scientist with an interest in pulmonary hypertension. The Editors and their hugely knowledgeable list of contributors have provided a contemporary, comprehensive overview of the field in all of its complexity that will be vital for all levels of clinician, researcher and trainee in respiratory medicine, cardiology, critical care and all disciplines involved in the management of patients with pulmonary hypertension. 606 $aPulmonary hypertension 606 $aHypertension, Pulmonary 615 0$aPulmonary hypertension. 615 2$aHypertension, Pulmonary 676 $a610 702 $aMaron$b Bradley A$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aZamanian$b Roham T$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aWaxman$b Aaron B$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910254515603321 996 $aPulmonary Hypertension$92049429 997 $aUNINA