LEADER 04385nam 22006135 450 001 9910254508803321 005 20200701150718.0 010 $a3-319-24085-4 024 7 $a10.1007/978-3-319-24085-5 035 $a(CKB)3710000000627440 035 $a(EBL)4461632 035 $a(SSID)ssj0001654115 035 $a(PQKBManifestationID)16433647 035 $a(PQKBTitleCode)TC0001654115 035 $a(PQKBWorkID)14982967 035 $a(PQKB)10000228 035 $a(DE-He213)978-3-319-24085-5 035 $a(MiAaPQ)EBC4461632 035 $a(PPN)192773887 035 $a(EXLCZ)993710000000627440 100 $a20160330d2016 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aOCT in Central Nervous System Diseases $eThe Eye as a Window to the Brain /$fedited by Andrzej Grzybowski, Piero Barboni 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (343 p.) 300 $aDescription based upon print version of record. 311 $a3-319-24083-8 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aIntroduction -- OCT Technique ? Past, Present and Future -- Optic Disc Edema -- Compressive Optic Neuropathy -- Multiple Sclerosis -- Parkinson?s Disease -- Alzheimer?s Disease -- Friedreichs Ataxia and More --  Other Neurological Disorders: Migraine, Neurosarcoidosis, Schizophrenia, Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) -- Hereditary Optic Neuropathies -- Trans Neuronal Retrograde Degeneration -- New OCT Technology in Neuro-Ophthalmology -- OCT and Pharmacological Treatment -- Animal Models in Neuro-Ophthalmology -- OCT in Glaucoma -- OCT in Amblyopia -- Conclusions. 330 $aThis book reviews recent important advances in the use of optical coherence tomography (OCT) in order to analyze neurodegeneration within the retina through the quantification of axonal loss. Detailed information is provided on the role of OCT as a promising tool for the evaluation of disease progression in numerous neurodegenerative disorders and as a biological marker of neuroaxonal injury. The disorders considered include multiple sclerosis, Parkinson?s disease, Alzheimer?s disease, intracranial hypertension, Friedreich?s ataxia, schizophrenia, hereditary optic neuropathies, glaucoma, and amblyopia. Individual chapters are also devoted to OCT technique, new OCT technology in neuro-ophthalmology, OCT and pharmacological treatment, and the use of OCT in animal models. As well as being a valuable tool for diagnosis of many retinal diseases and monitoring of surgical and medical treatment, OCT allows study of the retinal nerve fiber layer (RNFL) containing the axons of the retinal ganglion cells, which form the optic nerves, chiasm, and optic tracts. Since retinal axons are nonmyelinated until they penetrate the lamina cribrosa, the RNFL is an ideal structure for visualization of any process of neurodegeneration, neuroprotection, or regeneration. It is for this reason that OCT has been applied in various areas of neurology over the past decade, becoming a hot topic and generating great enthusiasm among neurologists and ophthalmologists. By documenting the ability of OCT to provide key information on CNS diseases, this book illustrates convincingly that the eye is indeed the ?window to the brain?. 606 $aOphthalmology 606 $aNeurology  606 $aRadiology 606 $aOphthalmology$3https://scigraph.springernature.com/ontologies/product-market-codes/H44004 606 $aNeurology$3https://scigraph.springernature.com/ontologies/product-market-codes/H36001 606 $aImaging / Radiology$3https://scigraph.springernature.com/ontologies/product-market-codes/H29005 615 0$aOphthalmology. 615 0$aNeurology . 615 0$aRadiology. 615 14$aOphthalmology. 615 24$aNeurology. 615 24$aImaging / Radiology. 676 $a616.804757 702 $aGrzybowski$b Andrzej$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aBarboni$b Piero$4edt$4http://id.loc.gov/vocabulary/relators/edt 906 $aBOOK 912 $a9910254508803321 996 $aOCT in Central Nervous System Diseases$92511956 997 $aUNINA