LEADER 03731nam  22005415  450 
001 9910254487003321
005 20200701134424.0
010   $a3-319-50353-7
024 7 $a10.1007/978-3-319-50353-0
035   $a(CKB)4340000000223199
035   $a(DE-He213)978-3-319-50353-0
035   $a(MiAaPQ)EBC5153638
035   $a(PPN)221253785
035   $a(EXLCZ)994340000000223199
100   $a20171122d2017      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aAlternatives for Dermal Toxicity Testing /$fedited by Chantra Eskes, Erwin van Vliet, Howard I. Maibach
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (XX, 592 p. 92 illus., 61 illus. in color.) 
311   $a3-319-50351-0 
320   $aIncludes bibliographical references at the end of each chapters.
327   $aIntroduction -- Concepts -- Skin irritation -- Skin corrosion -- Skin sensitization -- UV-induced effects (phototoxicity & photoallergy) -- Skin genotoxicity -- Other exploratory areas of relevance.
330   $aThis book provides comprehensive information on the alternative (non-animal) dermal toxicity test methods currently available for industrial, regulatory, and academic use and also explores potential future developments. It encompasses all areas of dermal toxicity, including skin irritation, skin corrosion, skin sensitization, UV-induced effects, and skin genotoxicity. An individual chapter is devoted to each test method, with coverage of the scientific basis, validation status and regulatory acceptance, applications and limitations, available protocols, and potential role within testing strategies. In addition, perspectives from the test developer are presented, for example regarding critical steps in the protocol, possible adaptations, and challenges and opportunities. The closing section addresses exploratory areas that may be of relevance for the future of dermal toxicity safety testing, including the validation and regulatory acceptance of integrated testing strategies, the use of alternative methods for infections and inflammatory diseases, novel complex skin models, and high-throughput screening techniques. Dermal toxicity is an area in which alternatives to the use of animal testing have already gained scientific, industrial, and regulatory acceptance. Practitioners and researchers alike will find Alternatives for Dermal Toxicity Testing to be an ideal source of reliable, up-to-date information on all aspects of the available test methods and likely future directions.
606   $aDermatology
606   $aPharmacology
606   $aAnimal models in research
606   $aDermatology$3https://scigraph.springernature.com/ontologies/product-market-codes/H1900X
606   $aPharmacology/Toxicology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21007
606   $aAnimal Models$3https://scigraph.springernature.com/ontologies/product-market-codes/L25050
615  0$aDermatology.
615  0$aPharmacology.
615  0$aAnimal models in research.
615 14$aDermatology.
615 24$aPharmacology/Toxicology.
615 24$aAnimal Models.
676   $a616.5
702   $aEskes$b Chantra$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $avan Vliet$b Erwin$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aMaibach$b Howard I$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910254487003321
996   $aAlternatives for Dermal Toxicity Testing$91551254
997   $aUNINA