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010   $a3-319-39147-X
024 7 $a10.1007/978-3-319-39147-2
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035   $a(MiAaPQ)EBC4935648
035   $a(DE-He213)978-3-319-39147-2
035   $a(PPN)203852648
035   $a(EXLCZ)993710000001631443
100   $a20170802d2017      u|             0
101 0 $aeng
135   $aurcnu||||||||
181   $2rdacontent
182   $2rdamedia
183   $2rdacarrier
200 10$aBiomarkers of the Tumor Microenvironment$b[electronic resource] $eBasic Studies and Practical Applications /$fedited by Lars A. Akslen, Randolph S. Watnick
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (536 pages)
311   $a3-319-39145-3 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $aMarkers of tumor-vascular interactions -- Extracellular matrix, especially integrins, importance for tumor progression -- Role of Axl for epithelial-mesenchymal transition and tumor spread -- Models of tumour progression in prostate cancer -- Biomarkers of tumor progression in malignant melanoma -- Biomarker signatures and tumor progress in breast cancer -- Biomarker panels and contemporary practice in clinical trials of targeted treatment -- Role of prosaposin in niche regulation and metastatic spread -- Regulators of microenvironment and metastases in prostate cancer -- Semaphorins and angiogenesis -- Heterogeneity of angiogenesis phenotypes -- Biology of metastatic niches -- Lymphangiogenesis and tumor progress -- Extracellular matrix -- Paracrine signalling and tumor progress -- Cancer associated fibroblasts -- Tumor immunology -- Interleukins and inflammatory programs in tumor progress -- Global gene expression signatures of the tumor microenvironment -- Microarray analysis of the tumour microenvironment -- Studies of the tumor microenvironment.
330   $aThis book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in the cancer field, and also cancer researchers from other backgrounds, especially those using morphology techniques and models focusing on cross-talk between different cell types in tumors.
606   $aPathology
606   $aCancer research
606   $aPathology$3https://scigraph.springernature.com/ontologies/product-market-codes/H4800X
606   $aCancer Research$3https://scigraph.springernature.com/ontologies/product-market-codes/B11001
615  0$aPathology.
615  0$aCancer research.
615 14$aPathology.
615 24$aCancer Research.
676   $a616.994075
702   $aAkslen$b Lars A$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aWatnick$b Randolph S$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910254485203321
996   $aBiomarkers of the Tumor Microenvironment$91552945
997   $aUNINA