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010   $a3-319-47507-X
024 7 $a10.1007/978-3-319-47507-3
035   $a(CKB)3710000001109485
035   $a(DE-He213)978-3-319-47507-3
035   $a(MiAaPQ)EBC4822972
035   $a(PPN)19976705X
035   $a(EXLCZ)993710000001109485
100   $a20170315d2017      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 10$aBone Morphogenetic Proteins: Systems Biology Regulators /$fedited by Slobodan Vukicevic, Kuber T. Sampath
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (XII, 445 p. 43 illus., 32 illus. in color.) 
225 1 $aProgress in Inflammation Research,$x0379-0363
311   $a3-319-47505-3 
320   $aIncludes bibliographical references and index.
327   $aIntroduction -- BMPs: Historic and Future Perspectives -- BMP ? Biology -- BMPs in Development -- BMP signaling -- BMP Antagonists - Biology -- BMP and BMP Antagonists - Structure and Function -- BMPs in Orthopaedic Medicine: Promises and Challenges -- BMP6 and Bone Repair -- BMPs in Dental Medicine: Promises and Challenges -- BMPs in Spine -- BMPs in Articular Joints -- BMP Signaling & FOP -- BMP-7 Biology and its Therapeutic Utility for Chronic Kidney Diseases -- BMPs in Inflammation -- BMPs and Angiogenesis -- BMP Signaling in Iron Homeostasis -- BMP Signaling in Pulmonary Arterial Hypertension -- BMP Signaling and Cancer -- BMP Biology in Rare Diseases.
330   $aThis book focuses on the salient features of the biology of Bone Morphogenetic Proteins and the advances in our understanding of their structure and function and of downstream signaling, as well as their governance in systems biology from bone and dentin to kidney, cancer, diabetes, iron homeostasis and angiogenesis, including rare musculoskeletal disorders. BMPs, also referred to as growth and differentiation factors, are members of the TGF-beta superfamily and are highly conserved from fruit flies to mammals and are responsible for the formation of practically every organ during embryo development and involved in adult tissue injury and repair. BMPs establish their extracellular gradient by interacting with their respective antagonists and regulate their function through SMAD-dependent down-stream signaling effector genes. This volume is aimed at scientists and professionals dealing with metabolic disorders, nutrition, systems biology diseases, rare musculoskeletal conditions, and disorders related to iron metabolism, including anemia of chronic disease, hereditary hemochromatosis and beta thalassemia.
410  0$aProgress in Inflammation Research,$x0379-0363
606   $aImmunology
606   $aCytology
606   $aCytokines
606   $aGrowth factors
606   $aProteins
606   $aSystems biology
606   $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000
606   $aCell Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16008
606   $aCytokines and Growth Factors$3https://scigraph.springernature.com/ontologies/product-market-codes/L14120
606   $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040
606   $aSystems Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L15010
615  0$aImmunology.
615  0$aCytology.
615  0$aCytokines.
615  0$aGrowth factors.
615  0$aProteins.
615  0$aSystems biology.
615 14$aImmunology.
615 24$aCell Biology.
615 24$aCytokines and Growth Factors.
615 24$aProtein Science.
615 24$aSystems Biology.
676   $a616.079
702   $aVukicevic$b Slobodan$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aSampath$b Kuber T$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910254481703321
996   $aBone Morphogenetic Proteins: Systems Biology Regulators$91551931
997   $aUNINA