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024 7 $a10.1007/978-3-319-43365-3
035   $a(CKB)3710000000891729
035   $a(DE-He213)978-3-319-43365-3
035   $a(MiAaPQ)EBC4709285
035   $a(PPN)196325978
035   $a(EXLCZ)993710000000891729
100   $a20161003d2017      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 14$aThe Ageing Immune System and Health /$fedited by Valquiria Bueno, Janet M. Lord, Thomas A. Jackson
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (XII, 182 p. 19 illus., 11 illus. in color.) 
311 08$a3-319-43363-6 
311 08$a3-319-43365-2 
320   $aIncludes bibliographical references at the end of each chapters and index.
327   $a1. Introduction -- 2. Innate Immune Response and Ageing (neutrophils, monocytes, dendritic cells, DAMPs, PAMPs -- 3. Adaptive Immune Response and Aging (T and B lymphocytes, naïve, effector and memory phenotypes and functions) -- 4. Modulatory/Suppressive Cells and Ageing (T regulatory cells, B regulatory cells, Myeloid Derived Suppressor Cells, Modulatory Neutrophils, M1 and M2 macrophages) -- 5. Mucosal Immune System and Ageing -- 6. Epigenetics and Ageing -- 7. Cancer and Ageing -- 8. Infections/Vaccination and Ageing -- 9. Cytomegalovirus and immmunosenescence -- 10. Frailty and Ageing -- 11. Inflammation and Neurodegenerative Diseases and Ageing -- 12. Effects of chronic inflammatory diseases (chronic kidney disease, rheumatoid arthritis, crohns disease etc) on the ageing of the immune system -- 13. Interventions in Elderly focusing Immunosenescence (physical activity, nutrition, supplements).
330   $aThe present book intends to provide an update on immunosenescence and how deficiencies in the immune system contribute to a higher susceptibility to infections, decline in organ function, reduced vaccination responses, age-related disease and the ageing process itself, negatively affecting longevity. Our focus is on the main changes in immune system cells and their products occurring during the ageing process and the possible consequences for health and disease. This includes: discussion of the modulatory and/or suppressive mechanisms associated with the alterations in T regulatory cells, B regulatory cells and Myeloid Derived Suppressor cells; changes in the immune system observed in chronic neurodegenerative diseases, cancer, lung disease and frailty will also be discussed. Most importantly we provide recent literature information about possible interventions (focusing on physical activity) that could alleviate the negative effects of immunosenescence. The Ageing Immune System and Health is a comprehensive guide on the field intended to all physicians, researchers, professors and students interested on relationship between immune system, ageing and health. .
606   $aGeriatrics
606   $aAging
606   $aImmunology
606   $aCytology
606   $aGeriatrics
606   $aAgeing
606   $aImmunology
606   $aCell Biology
615  0$aGeriatrics.
615  0$aAging.
615  0$aImmunology.
615  0$aCytology.
615 14$aGeriatrics.
615 24$aAgeing.
615 24$aImmunology.
615 24$aCell Biology.
676   $a618.97
676   $a612.67
702   $aBueno$b Valquiria$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aLord$b Janet M$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aJackson$b Thomas A$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910254477403321
996   $aAgeing Immune System and Health$91758873
997   $aUNINA