LEADER 04456nam 22006495 450 001 9910254477003321 005 20230811001908.0 024 7 $a10.1007/978-981-10-2711-6 035 $a(CKB)3710000001072475 035 $a(DE-He213)978-981-10-2711-6 035 $a(MiAaPQ)EBC4811219 035 $a(PPN)198866844 035 $a(EXLCZ)993710000001072475 100 $a20170221d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aMoyamoya Disease Explored Through RNF213 $eGenetics, Molecular Pathology, and Clinical Sciences /$fedited by Akio Koizumi, Kazuhiro Nagata, Kiyohiro Houkin, Teiji Tominaga, Susumu Miyamoto, Shigeo Kure, Elizabeth Tournier-Lasserve 205 $a1st ed. 2017. 210 1$aSingapore :$cSpringer Nature Singapore :$cImprint: Springer,$d2017. 215 $a1 online resource (VIII, 185 p. 36 illus., 22 illus. in color.) 225 1 $aCurrent Topics in Environmental Health and Preventive Medicine,$x2364-8341 311 $a981-10-2710-2 311 $a981-10-2711-0 320 $aIncludes bibliographical references at the end of each chapters. 327 $aPart I: Prologue -- 1. A prologue to moyamoya disease and RNF213 -- 2. Concept of moyamoya Disease -- Part II: Genetic Epidemiology -- 3. Molecular Epidemiology in East Asian Countries and in the World -- Part III: Biochemistry, Function and Molecular Pathology -- 4. Molecular Biology of Mysterin/RNF213 -- 5. Physiological Role of Mysterin/RNF213 in Zebrafish -- 6. Pathological Investigation on RNF213: Animal Models Knockout and Transgenic Mice in Diabetes and Signal Transduction -- 7. Pathological Investigation on RNF213: Animal Models of Rnf213-knockout and Knock-in Mice -- 8. RNF213 and Circulating Factors in Patients with Moyamoya Disease -- 9. Genetics of Moyamoya beyond RNF213. Monogenic Moyamoya Syndromes -- Part IV: Clinical Management 10. Natural History and Long-term Clinical Outcome after Conservative and Surgical Management -- 11. Significance of RNF213 in Clinical Management in Japan -- 12. Significance of RNF213 in Clinical Management in China -- 13. The Different Forms of Moyamoya Disease and Their Clinical Management -- 14. Vascular Diseases Attributable to RNF213 Other than Moyamoya Disease -- Part V: Epilogue -- Future Clinical Perspectives on RNF213 in Moyamoya Disease. 330 $aThis book presents the latest findings on biological, epidemiological, and clinical investigations of RNF213, which is thought to be involved in many biological processes and plays a key role in cerebro- and cardiovascular disease . By discussing the epidemiology and genetic epidemiology of the disease with a particular focus on the molecular function of RNF213, research using animal models, diagnosis, therapy and clinical management around the world, this work makes a valuable contribution to the study of the disease. Moyamoya Disease Explored Through RNF213 is an indispensable resource for both beginning and experienced researchers, pediatricians, neurologists, and neurosurgeons who are seeking comprehensive information on adult and childhood stroke. 410 0$aCurrent Topics in Environmental Health and Preventive Medicine,$x2364-8341 606 $aNeurology 606 $aNervous system$xSurgery 606 $aPublic health 606 $aNeurology 606 $aNeurosurgery 606 $aPublic Health 615 0$aNeurology. 615 0$aNervous system$xSurgery. 615 0$aPublic health. 615 14$aNeurology. 615 24$aNeurosurgery. 615 24$aPublic Health. 676 $a616.13 702 $aKoizumi$b Akio$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aNagata$b Kazuhiro$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aHoukin$b Kiyohiro$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aTominaga$b Teiji$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aMiyamoto$b Susumu$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKure$b Shigeo$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aTournier-Lasserve$b Elizabeth$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254477003321 996 $aMoyamoya Disease Explored Through RNF213$91759912 997 $aUNINA