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010   $a3-319-45514-1
024 7 $a10.1007/978-3-319-45514-3
035   $a(CKB)3710000001127470
035   $a(DE-He213)978-3-319-45514-3
035   $a(MiAaPQ)EBC4833049
035   $a(PPN)199767041
035   $a(EXLCZ)993710000001127470
100   $a20170329d2017      u|         0
101 0 $aeng
135   $aurnn|008mamaa
181   $ctxt$2rdacontent
182   $cc$2rdamedia
183   $acr$2rdacarrier
200 14$aThe Blood Brain Barrier and Inflammation /$fedited by Ruth Lyck, Gaby Enzmann
205   $a1st ed. 2017.
210  1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017.
215   $a1 online resource (VI, 286 p. 32 illus., 24 illus. in color.) 
225 1 $aProgress in Inflammation Research,$x0379-0363
311   $a3-319-45512-5 
320   $aIncludes bibliographical references and index.
327   $aGeneral Introduction to Barrier Mechanisms in the Central Nervous System -- Topological Aspects of the Blood-brain and Blood cerebrospinal Fluid Barriers and their Relevance in Inflammation Research -- The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions -- Pathophysiology of the Bloodbrain Barrier in Neuroinflammatory Diseases -- Leakage at Blood-neural Barriers -- Blood-Brain Barrier Transporters and Neuroinflammation: Partners in Neuroprotection and in Pathology -- MicroRNAs in Brain Endothelium and Inflammation -- Blood-Brain Barrier Dysfunction during Central Nervous System Autoimmune Diseases -- Pathways Across the Blood Brain Barrier -- Neuroinflammation in Bacterial Meningitis -- Blood Vessels in the Brain: a Signaling Hub in Brain Tumor Inflammation.
330   $aWithin the central nervous system (CNS) the constantly changing blood stream is separated from the CNS parenchyma by the blood brain barrier (BBB) restricting passage to selected immune cells. Under pathological conditions, however, viruses, bacteria, parasites and autoaggressive immune cells can penetrate the barrier and contribute to CNS inflammation. The BBB actively contributes to neuroinflammation by presentation of chemokines, expression of cell adhesion molecules and alteration of barrier properties. As such, understanding the role of the BBB under healthy and pathological conditions is essential for the development of new drugs to efficiently combat inflammatory diseases of the CNS. This book presents a comprehensive collection of reviews that focus on the role of the BBB. Experts in the field share their insight on structural, topological and functional properties of the BBB. They elaborate on pathophysiological changes of the inflamed BBB such as permeability, transporter proteins and alterations in microRNAs and cytokine profile. Additional chapters on multiple sclerosis and bacterial meningitis provide in depth information on significant neuroinflammatory diseases. The selection is complemented by a review on the current understanding of the BBB as signaling hub in tumor pathogenesis in the brain.
410  0$aProgress in Inflammation Research,$x0379-0363
606   $aImmunology
606   $aNeurosciences
606   $aCell membranes 
606   $aInfectious diseases
606   $aCytokines
606   $aGrowth factors
606   $aImmunology$3https://scigraph.springernature.com/ontologies/product-market-codes/B14000
606   $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006
606   $aMembrane Biology$3https://scigraph.springernature.com/ontologies/product-market-codes/L16050
606   $aInfectious Diseases$3https://scigraph.springernature.com/ontologies/product-market-codes/H33096
606   $aCytokines and Growth Factors$3https://scigraph.springernature.com/ontologies/product-market-codes/L14120
615  0$aImmunology.
615  0$aNeurosciences.
615  0$aCell membranes .
615  0$aInfectious diseases.
615  0$aCytokines.
615  0$aGrowth factors.
615 14$aImmunology.
615 24$aNeurosciences.
615 24$aMembrane Biology.
615 24$aInfectious Diseases.
615 24$aCytokines and Growth Factors.
676   $a616.079
702   $aLyck$b Ruth$4edt$4http://id.loc.gov/vocabulary/relators/edt
702   $aEnzmann$b Gaby$4edt$4http://id.loc.gov/vocabulary/relators/edt
906   $aBOOK
912   $a9910254467803321
996   $aBlood Brain Barrier and Inflammation$91758882
997   $aUNINA