LEADER 06806oam 22014534 450 001 9910819363003321 005 20240402045030.0 010 $a1-4639-9542-3 010 $a1-4639-7705-0 035 $a(CKB)2550000000106241 035 $a(EBL)1606516 035 $a(SSID)ssj0000970544 035 $a(PQKBManifestationID)11526802 035 $a(PQKBTitleCode)TC0000970544 035 $a(PQKBWorkID)11000963 035 $a(PQKB)10398679 035 $a(MiAaPQ)EBC1606516 035 $a(Au-PeEL)EBL1606516 035 $a(CaPaEBR)ebr10566411 035 $a(OCoLC)864300778 035 $a(IMF)MFIEE2012001 035 $a(IMF)MFIEA2012001 035 $a(EXLCZ)992550000000106241 100 $a20020129d2012 uf 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aFinance & Development, March 2012 205 $a1st ed. 210 1$aWashington, D.C. :$cInternational Monetary Fund,$d2012. 215 $a1 online resource (60 p.) 225 1 $aFinance & Development 300 $a"Youth demanding change." 300 $aTwo columns to the page. 311 $a1-4639-4425-X 311 $a1-4519-2214-0 320 $aIncludes bibliographical references. 327 $aCover; Contents; Features; YOUTH FINDING A VOICE; Youth in the Balance: Frustrated and angry, the world's young people are demanding change; Making the Grade: Revamping what and how young people learn is the best way to help them and their home countries succeed; Scarred Generation: In advanced economies, the crisis sparked a huge increase in unemployment among younger workers that will take a long time to abate; Straight Talk Stolen Dreams: Our ability to set the world economy straight will decide the fate of today's young people; Voices of Youth: Around the world, young people speak out 327 $aALSO IN THIS ISSUEWill the Renminbi Rule?: The Chinese currency is on track to become more important globally, but is unlikely to challenge the dollar anytime soon; Protecting the Whole: Keeping individual financial institutions sound is not enough. A broader macroprudential approach is needed to safeguard the financial system; Ratings Game: Private credit rating agencies have been thrust into providing a public function because regulators have not come up with an alternative; Empowering Women Is Smart Economics: Closing gender gaps benefits countries as a whole, not just women and girls 327 $aPicture This: Growing Out of Poverty: Poverty in Latin America is at its lowest level in 20 years 330 3 $aYoung people, hardest hit by the global economic downturn, are speaking out and demanding change. F&D looks at the need to urgently address the challenges facing youth and create opportunities for them. Harvard professor David Bloom lays out the scope of the problem and emphasizes the importance of listening to young people in "Youth in the Balance." "Making the Grade" looks at how to teach today's young people what they need to get jobs. IMF Deputy Managing Director, Nemat Shafik shares her take on the social and economic consequences of youth unemployment in our "Straight Talk" column. "Scarred Generation" looks at the effects the global economic crisis had on young workers in advanced economies, and we hear directly from young people across the globe in "Voices of Youth." Renminbi's rise, financial system regulation, and boosting GDP by empowering women. Also in the magazine, we examine the rise of the Chinese currency, look at the role of the credit rating agencies, discuss how to boost the empowerment of women, and present our primer on macroprudential regulation, seen as increasingly important to financial stability. People in economics - C. Fred Bergsten, American Globalist. Back to basics - The multi-dimensional role of banks in our financial systems. 410 0$aFinance & Development; Finance & Development ;$vNo. 0049/001 517 3 $aF & D 517 3 $aFinance and development 606 $aYouth$xPolitical activity 606 $aYouth$xSocial conditions$y21st century 606 $aAchievement motivation in youth 606 $aFinance: General$2imf 606 $aLabor$2imf 606 $aMacroeconomics$2imf 606 $aMoney and Monetary Policy$2imf 606 $aBanks$2imf 606 $aDepository Institutions$2imf 606 $aMicro Finance Institutions$2imf 606 $aMortgages$2imf 606 $aEducation: General$2imf 606 $aEconomics of Gender$2imf 606 $aNon-labor Discrimination$2imf 606 $aUnemployment: Models, Duration, Incidence, and Job Search$2imf 606 $aMonetary Systems$2imf 606 $aStandards$2imf 606 $aRegimes$2imf 606 $aGovernment and the Monetary System$2imf 606 $aPayment Systems$2imf 606 $aFinance$2imf 606 $aLabour$2imf 606 $aincome economics$2imf 606 $aEducation$2imf 606 $aMonetary economics$2imf 606 $aGender studies$2imf 606 $awomen & girls$2imf 606 $aCredit rating agencies$2imf 606 $aWomen$2imf 606 $aUnemployment$2imf 606 $aFinancial markets$2imf 606 $aGender$2imf 606 $aReserve currencies$2imf 606 $aMoney$2imf 606 $aCredit ratings$2imf 607 $aUnited States$2imf 615 0$aYouth$xPolitical activity. 615 0$aYouth$xSocial conditions 615 0$aAchievement motivation in youth. 615 7$aFinance: General 615 7$aLabor 615 7$aMacroeconomics 615 7$aMoney and Monetary Policy 615 7$aBanks 615 7$aDepository Institutions 615 7$aMicro Finance Institutions 615 7$aMortgages 615 7$aEducation: General 615 7$aEconomics of Gender 615 7$aNon-labor Discrimination 615 7$aUnemployment: Models, Duration, Incidence, and Job Search 615 7$aMonetary Systems 615 7$aStandards 615 7$aRegimes 615 7$aGovernment and the Monetary System 615 7$aPayment Systems 615 7$aFinance 615 7$aLabour 615 7$aincome economics 615 7$aEducation 615 7$aMonetary economics 615 7$aGender studies 615 7$awomen & girls 615 7$aCredit rating agencies 615 7$aWomen 615 7$aUnemployment 615 7$aFinancial markets 615 7$aGender 615 7$aReserve currencies 615 7$aMoney 615 7$aCredit ratings 676 $a346.73082 712 02$aInternational Monetary Fund. 801 0$bDcWaIMF 906 $aBOOK 912 $a9910819363003321 996 $aFinance & Development, March 2012$93960048 997 $aUNINA LEADER 04117nam 22006735 450 001 9910254264303321 005 20230810185400.0 010 $a3-319-30567-0 024 7 $a10.1007/978-3-319-30567-7 035 $a(CKB)3710000000685952 035 $a(EBL)4530168 035 $a(DE-He213)978-3-319-30567-7 035 $a(MiAaPQ)EBC4530168 035 $a(PPN)194077322 035 $a(EXLCZ)993710000000685952 100 $a20160519d2016 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aSperm Acrosome Biogenesis and Function During Fertilization /$fedited by Mariano G. Buffone 205 $a1st ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (176 p.) 225 1 $aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v220 300 $aDescription based upon print version of record. 311 $a3-319-30565-4 320 $aIncludes bibliographical references at the end of each chapters. 327 $aPreface -- The acrosome reaction: a historical perspective -- The acrosomal matrix -- Role of ion channels in the sperm acrosome reaction -- The molecules of sperm exocytosis -- Sperm capacitation and acrosome reaction in mammalian sperm -- Lipid regulation of acrosome exocytosis -- Role of actin cytoskeleton during mammalian sperm acrosomal exocytosis -- Site of mammalian sperm acrosome reaction. 330 $aOver the last decades, acrosomal exocytosis (also called the ?acrosome reaction?) has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reported in neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process. . 410 0$aAdvances in Anatomy, Embryology and Cell Biology,$x2192-7065 ;$v220 606 $aHuman physiology 606 $aMedicine$xResearch 606 $aBiology$xResearch 606 $aReproductive health 606 $aUrology 606 $aHuman Physiology 606 $aBiomedical Research 606 $aReproductive Medicine 606 $aUrology 615 0$aHuman physiology. 615 0$aMedicine$xResearch. 615 0$aBiology$xResearch. 615 0$aReproductive health. 615 0$aUrology. 615 14$aHuman Physiology. 615 24$aBiomedical Research. 615 24$aReproductive Medicine. 615 24$aUrology. 676 $a571.845 702 $aBuffone$b Mariano G$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254264303321 996 $aSperm Acrosome Biogenesis and Function During Fertilization$92519687 997 $aUNINA