LEADER 04871nam 22007335 450 001 9910254171303321 005 20200704074109.0 010 $a3-319-41475-5 024 7 $a10.1007/978-3-319-41475-1 035 $a(CKB)3710000000861979 035 $a(DE-He213)978-3-319-41475-1 035 $a(MiAaPQ)EBC4689334 035 $a(PPN)195512006 035 $a(EXLCZ)993710000000861979 100 $a20160914d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aBiomechanics: Trends in Modeling and Simulation /$fedited by Gerhard A. Holzapfel, Ray W. Ogden 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (IX, 316 p. 129 illus., 63 illus. in color.) 225 1 $aStudies in Mechanobiology, Tissue Engineering and Biomaterials,$x1868-2006 ;$v20 311 $a3-319-41473-9 320 $aIncludes bibliographical references at the end of each chapters and indexes. 327 $aMixture theory for modeling biological tissues: illustrations from articular cartilage -- A bio-chemo-mechanical model for cell contractility, adhesion, signaling and stress-fiber remodeling -- Nonlinear continuum mechanics and modeling the elasticity of soft biological tissues with a focus on artery wall -- Microstructure and mechanics of human aortas in health and disease -- Arterial and atherosclerotic plaque biomechanics with application to stent angiopasty modeling -- Biomechanics of myocardial ischemia and infarction. 330 $aThe book presents a state-of-the-art overview of biomechanical and mechanobiological modeling and simulation of soft biological tissues. Seven well-known scientists working in that particular field discuss topics such as biomolecules, networks and cells as well as failure, multi-scale, agent-based, bio-chemo-mechanical and finite element models appropriate for computational analysis. Applications include arteries, the heart, vascular stents and valve implants as well as adipose, brain, collagenous and engineered tissues. The mechanics of the whole cell and sub-cellular components as well as the extracellular matrix structure and mechanotransduction are described. In particular, the formation and remodeling of stress fibers, cytoskeletal contractility, cell adhesion and the mechanical regulation of fibroblast migration in healing myocardial infarcts are discussed. The essential ingredients of continuum mechanics are provided. Constitutive models of fiber-reinforced materials with an emphasis on arterial walls and the myocardium are discussed and the important influence of residual stresses on material response emphasized. The mechanics and function of the heart, the brain and adipose tissues are discussed as well. Particular attention is focused on microstructural and multi-scale modeling, finite element implementation and simulation of cells and tissues. 410 0$aStudies in Mechanobiology, Tissue Engineering and Biomaterials,$x1868-2006 ;$v20 606 $aBiomedical engineering 606 $aMathematical models 606 $aMechanics 606 $aMechanics, Applied 606 $aBiomaterials 606 $aBiophysics 606 $aBiological physics 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 606 $aMathematical Modeling and Industrial Mathematics$3https://scigraph.springernature.com/ontologies/product-market-codes/M14068 606 $aTheoretical and Applied Mechanics$3https://scigraph.springernature.com/ontologies/product-market-codes/T15001 606 $aBiomaterials$3https://scigraph.springernature.com/ontologies/product-market-codes/Z13000 606 $aBiological and Medical Physics, Biophysics$3https://scigraph.springernature.com/ontologies/product-market-codes/P27008 615 0$aBiomedical engineering. 615 0$aMathematical models. 615 0$aMechanics. 615 0$aMechanics, Applied. 615 0$aBiomaterials. 615 0$aBiophysics. 615 0$aBiological physics. 615 14$aBiomedical Engineering and Bioengineering. 615 24$aMathematical Modeling and Industrial Mathematics. 615 24$aTheoretical and Applied Mechanics. 615 24$aBiomaterials. 615 24$aBiological and Medical Physics, Biophysics. 676 $a620 702 $aHolzapfel$b Gerhard A$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aOgden$b Ray W$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254171303321 996 $aBiomechanics: Trends in Modeling and Simulation$92088393 997 $aUNINA