LEADER 03915nam 22006255 450 001 9910254160003321 005 20200705155724.0 010 $a3-319-59460-5 024 7 $a10.1007/978-3-319-59460-6 035 $a(CKB)3710000001364471 035 $a(DE-He213)978-3-319-59460-6 035 $a(MiAaPQ)EBC4858651 035 $a(PPN)201468581 035 $a(EXLCZ)993710000001364471 100 $a20170515d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aAlzheimer?s Disease II /$fedited by Michael S. Wolfe 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (VII, 202 p. 90 illus., 33 illus. in color.) 225 1 $aTopics in Medicinal Chemistry,$x1862-2461 ;$v24 311 $a3-319-59459-1 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aTargets and Strategies Toward the Development of Alzheimer Therapeutics -- The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer?s Disease -- ?-Secretase Modulators as A?42-Lowering Pharmacological Agents to Treat Alzheimer?s Disease -- Inhibitors of Tau-Phosphorylating Kinases -- Microtubule-Stabilizing Agents for Alzheimer?s and Other Tauopathies -- PET Imaging Agents for Alzheimer?s Disease. 330 $aMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors . 410 0$aTopics in Medicinal Chemistry,$x1862-2461 ;$v24 606 $aMedicinal chemistry 606 $aPharmaceutical technology 606 $aProteins  606 $aNeurosciences 606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aPharmaceutical Sciences/Technology$3https://scigraph.springernature.com/ontologies/product-market-codes/B21010 606 $aReceptors$3https://scigraph.springernature.com/ontologies/product-market-codes/L14110 606 $aNeurosciences$3https://scigraph.springernature.com/ontologies/product-market-codes/B18006 615 0$aMedicinal chemistry. 615 0$aPharmaceutical technology. 615 0$aProteins . 615 0$aNeurosciences. 615 14$aMedicinal Chemistry. 615 24$aPharmaceutical Sciences/Technology. 615 24$aReceptors. 615 24$aNeurosciences. 676 $a616.831 702 $aWolfe$b Michael S$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254160003321 996 $aAlzheimer?s Disease II$92214312 997 $aUNINA