LEADER 03769nam 22005895 450 001 9910254158803321 005 20200705192256.0 010 $a3-319-41818-1 024 7 $a10.1007/978-3-319-41818-6 035 $a(CKB)4340000000061672 035 $a(DE-He213)978-3-319-41818-6 035 $a(MiAaPQ)EBC4922004 035 $a(PPN)203666437 035 $a(EXLCZ)994340000000061672 100 $a20170721d2017 u| 0 101 0 $aeng 135 $aurnn|008mamaa 181 $ctxt$2rdacontent 182 $cc$2rdamedia 183 $acr$2rdacarrier 200 10$aProtein Therapeutics /$fedited by Zuben E. Sauna, Chava Kimchi-Sarfaty 205 $a1st ed. 2017. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2017. 215 $a1 online resource (XIII, 182 p.) 225 1 $aTopics in Medicinal Chemistry,$x1862-2461 ;$v21 311 $a3-319-41816-5 320 $aIncludes bibliographical references at the end of each chapters and index. 327 $aProtein Production in Eukaryotic Cells -- Production of Protein Therapeutics in the Quality by Design (QbD) Paradigm -- Characterization of Therapeutic Proteins -- Immunogenicity Lessons Learned from the Clinical Development of Vatreptacog Alfa, A Recombinant Activated Factor VII Analog, in Hemophilia with Inhibitors -- The Art of Gene Redesign and Recombinant Protein Production: Approaches and Perspectives. 330 $aMedicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors. 410 0$aTopics in Medicinal Chemistry,$x1862-2461 ;$v21 606 $aMedicinal chemistry 606 $aBiomedical engineering 606 $aProteins  606 $aMedicinal Chemistry$3https://scigraph.springernature.com/ontologies/product-market-codes/C28000 606 $aBiomedical Engineering and Bioengineering$3https://scigraph.springernature.com/ontologies/product-market-codes/T2700X 606 $aProtein Science$3https://scigraph.springernature.com/ontologies/product-market-codes/L14040 615 0$aMedicinal chemistry. 615 0$aBiomedical engineering. 615 0$aProteins . 615 14$aMedicinal Chemistry. 615 24$aBiomedical Engineering and Bioengineering. 615 24$aProtein Science. 676 $a615.19 702 $aSauna$b Zuben E$4edt$4http://id.loc.gov/vocabulary/relators/edt 702 $aKimchi-Sarfaty$b Chava$4edt$4http://id.loc.gov/vocabulary/relators/edt 801 0$bMiAaPQ 801 1$bMiAaPQ 801 2$bMiAaPQ 906 $aBOOK 912 $a9910254158803321 996 $aProtein Therapeutics$91561706 997 $aUNINA