LEADER 05454nam 22007815 450 001 9910254067703321 005 20251113184451.0 010 $a3-319-27598-4 024 7 $a10.1007/978-3-319-27598-7 035 $a(CKB)3710000000627472 035 $a(EBL)4460315 035 $a(SSID)ssj0001654100 035 $a(PQKBManifestationID)16433085 035 $a(PQKBTitleCode)TC0001654100 035 $a(PQKBWorkID)14982364 035 $a(PQKB)11027015 035 $a(DE-He213)978-3-319-27598-7 035 $a(MiAaPQ)EBC4460315 035 $a(PPN)192772511 035 $a(EXLCZ)993710000000627472 100 $a20160330d2016 u| 0 101 0 $aeng 135 $aur|n|---||||| 181 $ctxt 182 $cc 183 $acr 200 10$aModeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics $eHomogeneous and Heterogeneous Approaches /$fby Panos Macheras, Athanassios Iliadis 205 $a2nd ed. 2016. 210 1$aCham :$cSpringer International Publishing :$cImprint: Springer,$d2016. 215 $a1 online resource (497 p.) 225 1 $aInterdisciplinary Applied Mathematics,$x2196-9973 ;$v30 300 $aDescription based upon print version of record. 311 08$a3-319-27596-8 320 $aIncludes bibliographical references and index. 327 $aPart I: Basic Concepts -- The Geometry of Nature -- Diffusion and Kinetics -- Nonlinear Dynamics -- Part II: Modeling in Biopharmaceutics -- Drug Release -- Drug Dissolution -- Oral Drug Absorption -- Part III: Modeling in Pharmacokinetics -- Empirical Models -- Deterministic Compartmental Models -- Fractional Pharmacokinetics -- Modeling and Simulation in Bioequivalence -- Stochastic Compartmental Models -- Part IV: Modeling in Pharmacodynamics -- Classical Pharmacodynamics -- Nonclassical Pharmacodynamics -- Appendices. 330 $aThe state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this new second edition book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with epirical, compartmental, and stochastic pharmacokinetic models, with two new chapters, one on fractional pharmacokinetics and one on bioequivalence; and the fourth mainly with classical and nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. This second edition has new information on reaction limited models of dissolution, non binary biopharmaceutic classification system, time varying models, and interface models. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. This book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology. Reviews of the first edition: "This book presents a novel modelling approach to biopharmaceutics, pharmacokinetics and pharmacodynamic phenomena. This state-of-the-art volume will be helpful to students and researchers in pharmacology, bioengineering, and physiology. This book is a must for pharmaceutical researchers to keep up with recent developments in this field." (P. R. Parthasarathy, Zentralblatt MATH, Vol. 1103 (5), 2007) "These authors are the unique (or sole) contributors in this area that are working on these questions and bring a special expertise to the field that isnow being recognized as essential to understanding biological system and kinetic/dynamic characteristics in drug development...This text is an essential primer for those who would envision the incorporation of heterogeneous approaches to systems where homogeneous approaches are not sufficient to describe the system." (Robert R. Bies, Journal of Clinical Pharmacology, Vol. 46, 2006). 410 0$aInterdisciplinary Applied Mathematics,$x2196-9973 ;$v30 606 $aBiomathematics 606 $aPharmacology 606 $aBiophysics 606 $aBiomedical engineering 606 $aBiochemistry 606 $aMathematics 606 $aMathematical and Computational Biology 606 $aPharmacology 606 $aBiophysics 606 $aBiomedical Engineering and Bioengineering 606 $aBiochemistry 606 $aApplications of Mathematics 615 0$aBiomathematics. 615 0$aPharmacology. 615 0$aBiophysics. 615 0$aBiomedical engineering. 615 0$aBiochemistry. 615 0$aMathematics. 615 14$aMathematical and Computational Biology. 615 24$aPharmacology. 615 24$aBiophysics. 615 24$aBiomedical Engineering and Bioengineering. 615 24$aBiochemistry. 615 24$aApplications of Mathematics. 676 $a510 700 $aMacheras$b P$g(Panos),$4aut$4http://id.loc.gov/vocabulary/relators/aut$01351088 702 $aIliadis$b Athanassios$4aut$4http://id.loc.gov/vocabulary/relators/aut 906 $aBOOK 912 $a9910254067703321 996 $aModeling in Biopharmaceutics, Pharmacokinetics and Pharmacodynamics$94476468 997 $aUNINA