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024 7 $a10.1007/978-3-658-13234-7
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035   $a(EBL)4454269
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035   $a(PQKBTitleCode)TC0001653989
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035   $a(DE-He213)978-3-658-13234-7
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035   $a(PPN)192770985
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100   $a20160317d2016      u|         0
101 0 $aeng
135   $aur|n|---|||||
181   $ctxt
182   $cc
183   $acr
200 10$aAnalysis of Single-Cell Data $eODE Constrained Mixture Modeling and Approximate Bayesian Computation /$fby Carolin Loos
205   $a1st ed. 2016.
210  1$aWiesbaden :$cSpringer Fachmedien Wiesbaden :$cImprint: Springer Spektrum,$d2016.
215   $a1 online resource (108 p.)
225 1 $aBestMasters,$x2625-3615
300   $aDescription based upon print version of record.
311   $a3-658-13233-7 
320   $aIncludes bibliographical references.
327   $aModeling and Parameter Estimation for Single-Cell Data -- ODE Constrained Mixture Modeling for Multivariate Data -- Approximate Bayesian Computation Using Multivariate Statistics.
330   $aCarolin Loos introduces two novel approaches for the analysis of single-cell data. Both approaches can be used to study cellular heterogeneity and therefore advance a holistic understanding of biological processes. The first method, ODE constrained mixture modeling, enables the identification of subpopulation structures and sources of variability in single-cell snapshot data. The second method estimates parameters of single-cell time-lapse data using approximate Bayesian computation and is able to exploit the temporal cross-correlation of the data as well as lineage information. Contents Modeling and Parameter Estimation for Single-Cell Data ODE Constrained Mixture Modeling for Multivariate Data Approximate Bayesian Computation Using Multivariate Statistics Target Groups Researchers and students in the fields of (bio-)mathematics, statistics, bioinformatics System biologists, biostatisticians, bioinformaticians The Author Carolin Loos is currently doing her PhD at the Institute of Computational Biology at the Helmholtz Zentrum München. She is member of the junior research group ?Data-driven Computational Modeling?.
410  0$aBestMasters,$x2625-3615
606   $aBiomathematics
606   $aMathematics$xData processing
606   $aBioinformatics
606   $aMathematical and Computational Biology
606   $aComputational Mathematics and Numerical Analysis
606   $aComputational and Systems Biology
615  0$aBiomathematics.
615  0$aMathematics$xData processing.
615  0$aBioinformatics.
615 14$aMathematical and Computational Biology.
615 24$aComputational Mathematics and Numerical Analysis.
615 24$aComputational and Systems Biology.
676   $a510
700   $aLoos$b Carolin$4aut$4http://id.loc.gov/vocabulary/relators/aut$0755825
906   $aBOOK
912   $a9910254061003321
996   $aAnalysis of single-cell data$91523145
997   $aUNINA